BACKGROUND We evaluated the performance of two different array-based techniques, a bead-based multiplex genotyping method (LQ; digene HPV Genotyping LQ Test, QIAGEN, Germany) and a DNA chip-based method using peptide nucleic acid probes (PANArray; PANArray HPV Genotyping Chip, Panagene, Korea), for detection of human papillomavirus (HPV) and genotyping of high-risk (HR) or probable high-risk (P...

S AbstractWe analyze the robust stability of Inverse LQ regulators for single-input linear systems with uncertain input delay. Unlike the usual LQ regulator, the Inverse LQ regulator has a gain tuning parameter that can be chosen freely to some extent without losing its LQ optimality. Utilizing this freedom we seek the range of tuning parameter that ensures the robust stability against the unce...

Although the cholinesterase inhibitor tacrine has been successfully used for the treatment of Alzheimer's disease, it is known to have hepatotoxic effects. Liquiritigenin (LQ), an active flavonoid in Glycyrrhizae radix, exerts protective effects against liver damage. This study investigated the toxic effect of tacrine on hepatocytes and the beneficial effect of LQ on tacrine intoxication in viv...

Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification. However, the effects of LQ on cognitive function have not been fully explored. In this study, we evaluated the memory-enhancing effects of LQ and the underlying mechanisms with a focus on the N-...

This paper considers solving the unconstrained lq-norm (0 ≤ q < 1) regularized least squares (lq-LS) problem for recovering sparse signals in compressive sensing. We propose two highly efficient first-order algorithms via incorporating the proximity operator for nonconvex lq-norm functions into the fast iterative shrinkage/thresholding (FISTA) and the alternative direction method of multipliers...

Unlike Western medicine that generally uses purified compounds and aims to target a single molecule or pathway, traditional Chinese medicine (TCM) compositions usually comprise multiple herbs and components that are necessary for efficacy. Despite the very long-time and wide-spread use of TCM, there are very few direct comparisons of TCM and standard cytotoxic chemotherapy. In the present repor...

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The study uses different statistical methods to examine the change in territorial distribution and concentration of tertiary-educated population unemployed between 2001 2019. Among known regional inequality indicators measuring disparities, Dual index Hoover were used. With help location quotient (LQ), representation those with higher education relation average was explored represented at settl...

Glutamate has a key role in the neuronal cell damage associated with Alzheimer's and Parkinson's diseases. Liquiritin (LQ), a major constituent of Glycyrrhiza Radix, possesses various pharmacological activities. The present study investigated the neuroprotective effect of LQ against glutamate‑induced cell damage in the differentiated PC12 (DPC12) rat pheochromocytoma cell line. Pretreatment wit...

BACKGROUND Therapeutic strategies that induce effective neuroprotection and enhance intrinsic repair mechanisms are central goals for future treatment of multiple sclerosis (MS), as well as other diseases. Laquinimod (LQ) is an orally administered, central nervous system (CNS)-active immunomodulator with demonstrated efficacy in MS clinical trials and a favorable safety and tolerability profile...