Although medical evidence suggests that the mortality rates for cardiovascular disease can be significantly reduced by lowering blood cholesterol levels, cardiovascular disease ranks as the leading cause of mortality in the United States. Approximately 100 million American adults have total blood cholesterol levels of 200 milligrams per deciliter (mg/dL) and higher, and about 40 million of thes...

A simplified method for the analysis of both the glyceride-rich Sf 20-1 O5 and the cholesterol-rich St 0-20 lowdensity lipoproteins is presented. It consists of serum lipoprotein fractionation by preparative ultracentrifugation and subsequent quantitative analysis by refractometry. Comparison of this technique with the technically more difficult analytic ultracentrifugal methodology reveals com...

antioxidant consumption has been reported to be inversely associated with the incidence of coronary artery disease. to clarify the possible role of vitamin e and volatile oils in the prevention of atherosclerosis, the effects of these compounds on the susceptibility of low-density lipoprotein (ldl) to oxidative modification were investigated. in this study, vitamin e and seven volatile oils “an...

We investigated the incidence of insulin resistance syndrome (IRS) according to the criteria of diagnoses suggested by the American College of Endocrinology/ American Association of Clinical Endocrinologists and the risk factors associated with the development of IRS. Among 2,048 subjects without a history of/or drug treatment for hypertension, diabetes, dyslipidemia with normal findings at bas...

nonenzymatic glycation of low density lipoprotein (ldl) is a reaction of glucose and other reducing sugars with apolipoprotein b100 (apo-b100) lysine residues. in diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. the objective of this study was to investigate in vitro effects of ?-tocopherol, ascorbic acid and lycopene on ldl glycatio...

we studied the effect of different concentrations of alpha-tocopherol on in vitro cupric ions induced oxidation of low density lipoproteins (ldl). human native ldl (50 µg protein/ml) oxidation was induced by 10 µmol/l of cuso4. conjugated dienes were measured spectrophotometrically for up to 440 minutes. the length of the lag phase (tlag), maximum velocity of the reaction (vmax) and the maximum...

The United Kingdom Prospective Diabetes Study (UKPDS) found that metformin reduces macrovascular complications in type 2 diabetic patients. To investigate the mechanisms involved we examined the effect of metformin on monocyte adhesion to human endothelial cells (ECs) induced by advanced glycation end-products (AGE), and on monocyte differentiation into macrophages and foam cell formation. Trea...

To cite: Mahajan K, Asotra S, Negi P. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015214254 DESCRIPTION A 19-year-old woman presented with dyspnoea, angina and exertional syncope for the past 1 year. She had an ejection systolic murmur in the aortic area radiating to the carotids. She had multiple skin xanthomas over her feet, knees, hands and buttocks (figur...

Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and -/ conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed...