Aim: Tumor growth inhibition (TGI) metrics estimated with longitudinal tumor size (TS) models have been shown to be predictive of overall survival (OS) in a variety of tumor types. Methods: TS data from 2490 patients with 1 line or refractory RCC who received temsirolimus, interferon, sunitinib, sorafenib or axitinib in 10 Phase 2 or Phase 3 studies were used. TGI metrics (Early tumor shrinkage...

The penalized least squares interpretation of the classical random effects estimator suggests a possible way forward for quantile regression models with a large number of “fixed effects”. The introduction of a large number of individual fixed effects can significantly inflate the variability of estimates of other covariate effects. Regularization, or shrinkage of these individual effects toward...

Generalized linear mixed models are a widely used tool for modeling longitudinal data. However , their use is typically restricted to few covariates, because the presence of many predictors yields unstable estimates. The presented approach to the fitting of generalized linear mixed models includes an L 1-penalty term that enforces variable selection and shrinkage simultaneously. A gradient asce...

Objective: Potato is the fourth important food crop after wheat, rice and maize. Shrinkage  of  food  materials  has  a negative  consequence  on  the  quality  of  the dehydrated product. The main objective pursued in this paper is to investigate the shrinkage amount of potato slices during drying process using vacuum-infrared method. Methods: In this work, the effect of the infrared radiation...

Retinal imaging is limited due to optical aberrations caused by imperfections in the optical media of the eye. Consequently, diffraction limited retinal imaging can be achieved if optical aberrations in the eye are measured and corrected. Information about retinal pathology and structure on a cellular level is thus not available in a clinical setting but only from histologi‐ cal studies of exci...

Abstract The article proposes an analysis of the study turning a titanium-based alloy used for manufacture surgical implants. main focus is on machinability problems associated with choice rational cutting parameters, which determine quality and durability pedicle screws. conclusion made about need research aimed at ensuring maximum performance application practical data medical To carry out ex...

Shrinkage behavior of a geopolymer cement paste prepared from pumice-type natural pozzolan was studiedby changing parameters of chemical composition including SiO2/Na2O molar ratio of activator and total molar ratiosof Na2O/Al2O3, and H2O/Al2O3. For investigating the effect of curing conditions on shrinkage, hydrothermal curingwas also applied. The obtained results clearly revealed the governin...

The purpose of this study is to evaluate the long-term vertical deformations of segmented pre-tensioned concrete bridges by a new approach. It provides a practical and reliable method for calculating the amount of long-term deformation based on creep and shrinkage in segmented prestress bridges. There are various relationships for estimating the creep and shrinkage of concrete. The analytical r...