Background For industrial pharmaceutical protein production fast growing, high producing and robust cell lines are required. To select more pH shift permissive and fast growing sub-populations, the CHO DP-12 (ATCC clone #1934) cell line, an anti-IL8 antibody producing CHO K1 (DHFR) clone, was continuously subcultured at high viability (>90 %) for more than four hundred days in shaking flasks us...

introduction: to study the effect of gallic acid (ga) on hippocampal long-term potentiation (ltp) and histological changes in animal model of alzheimer disease (ad) induced by betaamyloid (aβ). methods: sixty-four adult male wistar rats (300±20 g) were divided into 8 groups: 1) control (cont); 2) ad; 3) sham; 4-7) ad+ga (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) cont+ga100, aβ ...

achillea millefolium belonging to the astreaceae family is an endangered medicinal plant of jordan and of its neighboring countries. as an alternative to seed propagation, an efficient micropropagation of a. millefolium and its subsequent rooting were developed as an option for its in vitro conservation. a maximum of 5.9 shoots per microshoot were obtained on murashige and skoog agar medium sup...

this study identifies and compares the antecedent of nigerian students’ perception on business social responsibility. part of its objectives is to examine the perception of business students in terms of importance of business social responsibility with respect to profitability, and the effectiveness of social responsibility in both long and short terms. the study reviews the related literature ...

introduction: verapamil, a phenylalkylamin –type ca2+ channel blocker, is widely used in the treatment of cardiovascular disorders especially as an antiaryhthmic and antiangina agent. theoretically, calcium can influence thyroid function and there are evidences that ca2+ channel blockers are able to interfere with thyroid function. in this study, the effects of chronic oral administration of ve...

Innovation is the soul of modern enterprise, and sustainable innovation is the essential for enterprises to keep their long-term energies. Small and medium enterprises should start from the construction of interior sustainable innovation ability cultivation system, cultivate innovational leading thinking, establish innovational enterprise culture, improve innovational encouragement system, walk...

Experimental studies have observed Long Term synaptic Potentiation (LTP) when a presynaptic neuron fires shortly before a postsynaptic neuron, and Long Term Depression (LTD) when the presynaptic neuron fires shortly after, a phenomenon known as Spike Timing Dependent Plasticity (STDP). When a neuron is presented successively with discrete volleys of input spikes STDP has been shown to learn 'ea...

A new behavioral training approach has been found significantly to improve visual function; the results further attest to the high degree of plasticity in sensory systems.