Intraepithelial lymphocytes (IEL) are specialized T cells found between the epithelial cells of the small intestine. Because of their location, IEL are the first lymphocytes to contact intestinal bacteria and food antigens. In the neonate, IEL may be the first cells of the immune system to interact with milk-borne hormones including prolactin (PRL). PRL, an endocrine hormone abundant in breast ...

Treatment with amantadine (AMA), an N-methyl-D-aspartate (NMDA) receptor antagonist and antidepressant drug, increased the antidepressant activity of subsequent drugs in experimental studies and in patients suffering from treatment-resistant depression (TRD). Recent evidence indicates that depression may be accompanied by activation of an inflammatory response. These data indicate that pro-infl...

Modulation and suppression of the immune response of the host by nematode parasites have been reported extensively and the migration inhibitory factor (MIF) is identified as one of the major immunomodulator. In the present study, we cloned and produced recombinant MIF protein from the small ruminant's nematode parasite Haemonchus contortus (rHCMIF-1), and investigated its immunomodulatory effec...

Abstract The tumor microenvironment in glioblastoma (GBM) contains numerous cell types, notably a rich immune compartment dominated by myeloid cells, such as brain-resident microglia and infiltrating macrophages. However, current immunotherapies target lymphoid components like T which are sparse the brain tumors originating there. Therefore, checkpoint drugs designed for systemic cancers have n...

iran is a developing country in middle east which has experienced some political and economical turbulence during the past decades. government of iran, after the 1979 islamic revolution, has devoted considerable resources on national health, including the pharmaceutical sector. as a result, health indicators have improved substantially over the past two decadesnd the availability and affordabil...

the partition coefficients (p-values) of certain new potential, stereoselective, reversible, long-acting local anesthetics have been determined in an n-octanol/ phosphate buffer system. these are derivatives of 2-phenoxyethyldialkylamine hydrochloride, and almost all of them are readily soluble in water. their aqueous solutions have shown different absorption maxima, and these have been used qu...

following our previous investigations on certain new aminoalkyl aryl ethers, which showed promising and outstanding local anaesthetic properties, the local anaesthetic activity and duration of action of a further selection of four novel derivatives of the above-mentioned series, used as hydrochloride salts, have been determined by the ill vivo rat sciatic nerve test. these are: n,n-dimethyl-2-(...