the effects of cholecystokinin (cck) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. in the present work, subcutaneous (sc) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. administration of ccka receptor antagonist mk-329 (0.5-1.5 mg/kg), cckb receptor antagonist l-365, 260 (0.5-1.5 mgl kg) and cck recept...

Hypoxic ischemic encephalopathy is a serious condition affecting newborn infants which can result in death and disability. There is now strong clinical evidence that moderate post-asphyxial total body cooling or hypothermia in full term neonates results in long-term neuroprotection, allowing us to proclaim this innovative therapy as "standard of care." The treatment is a time-critical emergency...

Muscle strength is reduced during hypothermia, both in the presence and in the absence of neuromuscular blocking drugs. A 2 degrees C reduction in body temperature may double the duration of neuromuscular blockade. Central body and muscle temperatures decline in parallel, as long as peripheral vasoconstriction does not occur. A reduction in muscle strength must be expected at a body temperature...

The effects of immersion hypothermia on the systemic and pulmonary circulations were investigated in anesthetized, closed-chest, untreated dogs, cold-adapted dogs and in dogs receiving sympathomimetic and sympatholytic agents. Evidence is presented that both pulmonary and systemic vascular resistances are increased progressively during hypothermia, the former to a greater extent than the latter...

Accidental hypothermia is associated with increased risk for arrhythmias. QRS/QTc proposed as an ECG-marker, where decreasing values predict hypothermia-induced ventricular If reliable it should also nonappearance of arrhythmias, observed in species like rat that regularly tolerate prolonged hypothermia. A model designed studying cardiovascular function during cooling, and subsequent rewarming ...

Wound infection following surgery is a relatively common and serious complication. Perioperative hypothermia increases risk of surgical wound infection by several mechanisms including cutaneous vasoconstriction and a decrease in the activity of the immune system. This paper reviews these mechanisms and concludes that both prevention of hypothermia and application of local and systemic heat may ...