Kaneko, Yukiko, Tomohisa Ishikawa, Satoshi Amano, and Koichi Nakayama. Dual effect of nitric oxide on cytosolic Ca2 concentration and insulin secretion in rat pancreatic -cells. Am J Physiol Cell Physiol 284: C1215–C1222, 2003. First published January 15, 2003; 10.1152/ajpcell.00223.2002.—In isolated rat pancreatic -cells, the nitric oxide (NO) donor NOC-7 at 1 M reduced the amplitude of the os...

BACKGROUND In periaqueductal grey (PAG) matter, cross-talk between the Mu-opioid receptor (MOR) and the glutamate N-methyl-D-Aspartate receptor (NMDAR)-CaMKII pathway supports the development of analgesic tolerance to morphine. In neurons, histidine triad nucleotide binding protein 1 (HINT1) connects the regulators of G protein signaling RGSZ1 and RGSZ2 to the C terminus of the MOR. In response...

OBJECT Oxidative stress involved in the regulation of arterial erectile dysfunction (A-ED). Previously report have indicated that quercetin have an antioxidant effect. In the current study, we have established the rats' model for study the therapeutic effect of quercetin on A-ED and further investigated the molecular mechanism of action. METHODS Wistar rats were divided into sham group, A-ED ...

We tested the hypothesis that stimulation of metabotropic glutamate receptors (mGluRs) increases nitric oxide (NO) production in the hippocampus in vivo. Microdialysis probes were placed bilaterally into the CA3 region of the hippocampus of adult Sprague-Dawley rats under pentobarbital anesthesia. Probes were perfused for 5 h with artificial cerebrospinal fluid (CSF) containing 3 microM [14C]-L...

Synoptic and satellite-derived cloud property variations for the southeast Pacific stratocumulus region associated with changes in coastal satellite-derived cloud droplet number concentrations (Nd ) are explored. MAX and MIN Nd composites are defined by the top and bottom terciles of daily area-mean Nd values over the Arica Bight, the region with the largest mean oceanic Nd , for the five Octob...

of North America. A total of about 1.5 million ha of durum is planted annually in the USA, with about 80% The accumulation of Cd in edible crops is undesirable because of concentrated in northern North Dakota. In some locapotential risks to human health. Agronomic efforts to lower Cd in foods will be more effective if we understand the extent and causes of spatial tions, durum wheat grain may e...

29 Reactive oxygen species (ROS) are essential in vascular homeostasis but may contribute to vascular 30 dysfunction when excessively produced. Superoxide anion (O2) can directly affect vascular tone by 31 reacting with K channels and indirectly by reacting with nitric oxide (NO) thereby scavenging NO and 32 causing nitroso-redox imbalance. After myocardial infarction (MI), oxidative stress inc...

N-nitro-arginine (NNA) is known to exhibit stereoselective pharmacokinetics in which N-nitro-D-arginine (D-NNA) has a faster clearance rate than N-nitro-L-arginine (L-NNA) in anesthetized rats, and D-NNA undergoes unidirectional chiral inversion. It was postulated that chiral inversion of D-NNA was performed in a twostep pathway by D-amino acid oxidase (DAAO) followed by an unidentified transam...

N-nitro-arginine (NNA) is known to exhibit stereoselective pharmacokinetics in which N-nitro-D-arginine (D-NNA) has a faster clearance rate than N-nitro-L-arginine (L-NNA) in anesthetized rats, and D-NNA undergoes unidirectional chiral inversion. It was postulated that chiral inversion of D-NNA was performed in a twostep pathway by D-amino acid oxidase (DAAO) followed by an unidentified transam...

N-nitro-arginine (NNA) is known to exhibit stereoselective pharmacokinetics in which N-nitro-D-arginine (D-NNA) has a faster clearance rate than N-nitro-L-arginine (L-NNA) in anesthetized rats, and D-NNA undergoes unidirectional chiral inversion. It was postulated that chiral inversion of D-NNA was performed in a twostep pathway by D-amino acid oxidase (DAAO) followed by an unidentified transam...