نتایج جستجو برای: lncrna

تعداد نتایج: 6925  

Journal: :European review for medical and pharmacological sciences 2017
J-J Qi Y-X Liu L Lin

OBJECTIVE To compare the expression of lncRNA-ATB in renal cell carcinoma (RCC) tissues and adjacent non-tumor tissues to determine whether lncRNA-ATB could be used as a potential prognostic biomarker for RCC. PATIENTS AND METHODS qRT-PCR was performed to determine the expression level of lncRNA-ATB in RCC tissues and corresponding non-tumor tissues. The relationship between lncRNA-ATB expres...

2017
Fei Xie Xudong Xiang Qionglin Huang Pengzhan Ran Yuncang Yuan Qian Li Guoxiang Qi Xiaopeng Guo Chunjie Xiao Shangyong Zheng

β-catenin plays a major role in tumor development and progression. The present study found that β-catenin was upregulated in 30 samples of colorectal cancer (CRC) tissue as compared to adjacent non-tumor tissues. Analysis of long non-coding RNA (lncRNA) expression profiles using the GSE18560 and GSE44097 datasets, which were generated via the Affymetrix plus 2.0 microarray platform and download...

2016
Yongsheng Li Zishan Wang Yuan Wang Zheng Zhao Jinwen Zhang Jianping Lu Juan Xu Xia Li

Long non-coding RNAs (lncRNAs) modulate gene expression, and lncRNA misregulation is associated with cancer. However, precise functional roles in biological and disease processes have been described for only a few lncRNAs. Identification of genome-wide lncRNA-mediated transcriptional dysregulations may improve cancer treatments. In the present study, we used a computational framework that combi...

2016
PENG-LI WANG BIN LIU YANG XIA CHUN-FENG PAN TENG MA YI-JIANG CHEN

Long non-coding RNAs (lncRNAs) are involved in governing fundamental biological processes, and, in many lncRNAs, the expression level is altered and likely to have a functional role in tumorigenesis, including apoptosis, migration and invasion. The lncRNA‑Low Expression in Tumor (LET), a recently identified lncRNA, was demonstrated to be downregulated in hepatocellular and gallbladder cancer. H...

Journal: :Molecular cell 2013
Fu Yang Xi-song Huo Sheng-xian Yuan Ling Zhang Wei-ping Zhou Fang Wang Shu-han Sun

Recently, long noncoding RNAs (lncRNAs) were found to be dysregulated in a variety of tumors. However, it remains unknown how and through what molecular mechanisms the expression of lncRNAs is controlled. In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. We...

Journal: :International journal of clinical and experimental pathology 2015
Chen-Yu Wang Long Hua Kun-Hou Yao Jiang-Tao Chen Jun-Jie Zhang Jun-Hong Hu

INTRODUCTION Dysregulation of long non-coding RNAs (lncRNAs) play important roles in tumor progression. The aim of our study was to explore the clinicopathologic and prognostic significance of lncRNA CCAT2 expression in human gastric cancer. METHODS Expression levels of lncRNA CCAT2 in 85 pairs of gastric cancer and adjacent non-tumor tissues were detected by quantitative real-time PCR (qRT-P...

2016
Kamlesh Pawar Carlos Hanisch Sergio Eliseo Palma Vera Ralf Einspanier Soroush Sharbati

Small non-coding RNA play a major part in host response to bacterial agents. However, the role of long non-coding RNA (lncRNA) in this context remains unknown. LncRNA regulate gene expression by acting e.g. as transcriptional coactivators, RNA decoys or microRNA sponges. They control development, differentiation and cellular processes such as autophagy in disease conditions. Here, we provide an...

Journal: :European review for medical and pharmacological sciences 2017
M Zhang W-B Wu Z-W Wang X-H Wang

OBJECTIVE Breast cancer (BC) is one of the most common cancers in females. Abnormal proliferation and metastasis are key reasons that cause mortality in BC patients. More and more evidence showed that lncRNA played an important role in the BC development, but the mechanism was not well established. PATIENTS AND METHODS The expression of lncRNA NEAT1 was detected in 40 BC patients by qRT-PCR t...

2017
Wanxin Tang Dongmei Zhang Xiaoke Ma

Background Diabetic nephropathy (DN) seriously threatens the lives of patients, and the mechanism of DN remains largely unknown because of the complex regulation between long non-coding RNA (lncRNA) and protein-coding genes. In early development of diabetic nephropathy (DN), pathogenesis remains largely unknown. Results We used RNA-sequencing to profile protein-coding and lncRNA gene transcri...

2016
Jixuan Ma Xiuqing Cui Yi Rong Yun Zhou Yanjun Guo Min Zhou Lili Xiao Weihong Chen

LncRNA-ATB (lncRNA was activated by transforming growth factor-β) has been reported to be involved in specific physiological and pathological processes in human diseases, and could serve as biomarkers for cancers. However, the role of lncRNA-ATB in coal workers' pneumoconiosis (CWP) is still unknown. This study aimed to investigate the association between lncRNA-ATB and CWP. Quantitative real-t...

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