We have examined the extent to which the systemic and renal vasoconstriction induced by nitric oxide (NO) inhibition in vivo are mediated by endothelin (ET). We examined'the effects of BQ610, a specific ET-A receptor antagonist, following NO inhibition with L-NAME in the anesthetized rat. Mean arterial pressure (MAP) increased following L-NAME infusion from 107±2 to 133+3 mmHg (p<0.05 vs baseli...

Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit. Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concent...

in this study we investigated the effects of endothelium removal and l-name on responses to α-adrenoceptor agonists. male wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 ml isolated organ bath, bathed in krebs maintained at 37°c...

introduction: the aim of the present study was to determine direct effects of no modulation on protective electrophysiological properties of atrioventricular node (av node) in the experimental model of af in rabbit. methods: isolated perfused rabbit av nodal preparations were used in two groups. in the first group (n=7), lname (50μm) was applied. in the second group (n=12), different concentrat...

Le Noble, Ferdinand A. C., Karin Ruijtenbeek, Susanne Gommers, Jo G. R. De Mey, and Carlos E. Blanco. Contractile and relaxing reactivity in carotid and femoral arteries of chicken embryos. Am J Physiol Heart Circ Physiol 278: H1261–H1268, 2000.—In the embryo, hypoxemia causes redistribution of cardiac output from the periphery toward the heart and the brain. In view of this, we investigated de...

Just, Armin, Heimo Ehmke, Uwe Wittmann, and Hartmut R. Kirchheim. Tonic and phasic influences of nitric oxide on renal blood flow autoregulation in conscious dogs. Am. J. Physiol. 276 (Renal Physiol. 45): F442–F449, 1999.—The aim of this study was to investigate the influence of the mean level and phasic modulation of NO on the dynamic autoregulation of renal blood flow (RBF). Transfer function...

Arachidonic acid (AA) metabolites from the 15-lipoxygenase-1 (15-LO-1) pathway, trihydroxyeicosatrienoic acids (THETAs) and hydroxy-epoxyeicosatrienoic acids (HEETAs), are endothelium derived hyperpolarizing factors (EDHFs) and relax rabbit arteries. Rabbit vascular 15-LO-1 expression, THETA and HEETA synthesis and nitric oxide (NO) and prostaglandin (PG)-independent relaxations to acetylcholin...

Erdely, Aaron, Gary Freshour, and Chris Baylis. Resistance to renal damage by chronic nitric oxide synthase inhibition in the Wistar-Furth rat. Am J Physiol Regul Integr Comp Physiol 290: R66–R72, 2006; doi:10.1152/ajpregu.00444.2005.—Chronic nitric oxide synthase inhibition (NOSI) causes chronic kidney disease (CKD) in the Sprague Dawley (SD) rat. We previously showed that the Wistar-Furth (WF...

Introduction: Nitric oxide (NO), as a free radical, involves in several physiologic functions in GI tract such as nerve impulse transmission and vascular tonicity regulation. Nitric oxide synthase (NOS) is the enzyme for the production of NO from L-Arginine which in turn inhibits by L-NGNitroarginine Methyl Ester (L-NAME). In the current work, we aimed to evaluate morphometric analysis of...

In this study we investigated the effects of endothelium removal and L-NAME on responses to α-adrenoceptor agonists. Male Wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 mL isolated organ bath, bathed in Krebs maintained at ...