Liver or hepatic transplantation (LT) is the replacement of a diseased liver with part or whole healthy liver from another person (allograft). Human liver transplants were first performed by Thomas Starzl in the United States and Roy Calne in Cambridge, England in 1963 and 1967, respectively. Liver transplantation is a viable treatment option for end-stage liver disease and acute liver failure....

Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...

conclusions the present study detected more accurate results for ann method compared to those of cox ph model to analyze the survival of patients with liver transplantation. furthermore, the order of effective factors in patients’ survival after transplantation was clinically more acceptable. the large dataset with a few missing data was the advantage of this study, the fact which makes the res...

background: including multivariate survival data can be pointed competing risks data. there are various methods to analyze such data such as semi-parametric methods of cause-specific hazard function, and cumulative incidence function. the aim of this study was to deploy competing risks model to analyze the determinants of patients with liver cirrhosis. materials and methods: during the one-year...

Liver transplantation (LT) is the only recognized effective treatment for end-stage liver disease (ESLD) and acute fulminant failure [...]

we assessed different systolic cardiac indices to detect left and right ventricular systolic dysfunction in cirrhotic patients before liver transplantation. between 2010-2011, 81 consecutive individuals with confirmed hepatic cirrhosis who were a candidate for liver transplantation were enrolled in this study. a total of 32 age and sex matched healthy volunteers were also selected as the contro...

introduction: cytomegalovirus (cytome-galovirus: cmv) infection is a common cause of morbidity and mortality in patients who are the candidate for liver transplant. serological monitoring of individuals rece-iving and giving the liver transplant is necessary for prevention, early diagnosis and treatment strategies and reducing the prevalence of infection. the aim of this study was to assess the...

background: biliary atresia is a 100% fatal disorder without any treatment in infants as a leading cause of cirrhosis and kasai operation, as the only operative choice, which plays a crucial role in increasing their rate of survival. nonetheless, many patients end up with liver transplantation in the future owing to various inevitable hepatic and biliary problems which do remain after the kasai...

conclusions exercise test performance was affected by lower quality of life and lower physical activity after lt. with the exception of hypertension, well known factors that affect the risk of coronary artery disease had no effect on the exercise test results. objectives this study examined potential relationships between physical activity, health-related quality of life (hrqol), risk factors f...

conclusions a comparison of our results with those obtained from other centers in both western and asian countries (which reported cca in 3.6% - 36.5% of patients with psc), shows that the incidence of cca in the patients we studied is intermediate. results of the 181 patients, 16 were found to have cca, two of whom had been diagnosed after pathologic study of the explanted livers. therefore it...