Cadmium (Cd) is an important industrial and environmental toxicant with many industrial applications. Cd emissions to the atmospheric, aquatic, and terrestrial environment have increased during the last century. Since Cd is not degraded in the environment, the risk of human exposure is constantly increased due to Cd also enters to the food chain [1]. Humans are generally exposed to Cd by two ma...

Objective(s): With the advent of nanotechnology, significant progress has been made in the area of nanoscale materials such as nanosilver (Ag-Nps). These nanoparticles have a wide range of applications and been used for antimicrobial purposes for more than a century. However, little attention has been paid to the toxicity of nanosilver wound dressing. This study was designed to investigate the ...

Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir di...

Thiazolidinediones or glitazones specifically target insulin resistance. They have proven efficacy for reducing plasma glucose levels of type 2 diabetic patients treated with diet alone, sulphonylureas, metformin or insulin. In addition, they may be associated to some improvement of cardiovascular risk profile. However, troglitazone, the first compound approved by the FDA in the US, proved to b...

To the Editor: An 84-year-old woman with a history of end-stage renal disease presented to the hospital with abdominal pain and bilious vomiting. On admission, she was found to have significant elevation in serum aminotransferases (AST 5 367 U/L and ALT 5 639 U/L,) and marginal elevation in alkaline phosphatase level (171 U/L). Basic metabolic panel was at her baseline. A thorough investigation...

In the recent era, use of various nutritional supplements is highly encouraged amongst the people of United States. Weight loss supplements are major part of the nutritional supplements and their usage is unregulated in the US. Obesity is a major health concern in the US and Americans spend around $30 billion a year for weight loss supplements. At times, these supplements can be responsible for...

Carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .Control mice received similar quantities of olive oil. Daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. The histologic e...