BACKGROUND AND AIM There is insufficient research on whether direct-acting antiviral (DAA) therapy can improve liver fibrosis in patients with chronic hepatitis C virus (HCV). We evaluated sequential changes in liver stiffness using shear wave elastography in patients with HCV who received DAA therapy. METHODS A total of 210 patients with HCV who received daclatasvir and asunaprevir therapy a...

OBJECTIVES Liver biopsy is indispensable because liver stiffness measurement alone cannot provide information on intrahepatic inflammation. However, the presence of fibrosis highly correlates with inflammation. We constructed a noninvasive model to determine significant inflammation in chronic hepatitis B patients by using liver stiffness measurement and serum markers. METHODS The training se...

Changes in liver structure are an important issue in chronic hepatopathies. Until the end of the 20th century, these changes could only be determined by histological analyses of a liver specimen obtained via biopsy. The well-known limitations of this technique (i.e., pain, bleeding and the need for sedation) have precluded its routine use in follow-up of patients with liver diseases. However, t...

Introduction Nonalcoholic fatty liver disease (NAFLD) is raising prevalence among children, and adolescence population in developed and developing countries as a major public health concern. The present study aims to determine the relationship between serum ferritin level and transient elastography findings in patients suffering from NAFLD. Materials and Methods The demographic and biochemica...

BACKGROUND The success of liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) is influenced by anthropometric factors. In smaller adults, the M probe may fail due to narrow intercostals spaces and rib interference. We aimed to compare LSM using the FibroScan S2 (pediatric) probe with the M probe in small adults with chronic liver disease. MATERIAL AND METHODS In this p...

A 29-year-old man was admitted to our hospital for further examination of elevated liver enzymes, hepatosplenomegaly, thrombocytopenia and pericardial/pleural effusions. Fibroscan (EchoSens, Paris, France) and supersonic shear imaging (Aixplorer Supersonic Imagine, Aixen-Provence, France) revealed increased liver stiffness, consistent with cirrhosis (Picture A). A liver biopsy was performed and...

OBJECTIVE The purpose of this article is to establish the range of normal splenic stiffness in healthy volunteers using MR elastography (MRE) and to investigate any correlation with physiologic parameters and driver position. SUBJECTS AND METHODS Sixteen volunteers (mean [+/- SD] age, 37 +/- 9 years) with no history of gastrointestinal, hepatobiliary, or cardiovascular disease were recruited....

BACKGROUND Transient elastography (FibroScan) is a new, non-invasive, rapid, and reproducible method allowing evaluation of liver fibrosis by measurement of liver stiffness. In cirrhotic patients, liver stiffness measurements range from 12.5 to 75.5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness ...

Because of the limitations of liver biopsy, there is strong interest in developing less invasive methods to assess liver fibrosis especially in children. Liver stiffness measurement (LSM) by transient elastography( TE) involves transmission of vibrations through the chest wall into the liver using an ultrasound probe with a vibration transducer, the elasticity of the liver is determined from th...

Methods: Liver MRI and MRE were performed in 32 subjects. The indications for liver MRE were suspected fibrosis/cirrhosis (n=24) and liver tumour (n=8). All MRI studies were performed on a single 1.5 Tesla clinical MR scanner (GE, Milwaukee, USA). The MRE was performed before (pre-Gd MRE) and at the end of standard Liver MRI protocol immediately after the 5 minute delayed phase (post-Gd MRE) in...