نتایج جستجو برای: liver injury drug

تعداد نتایج: 1106915  

Journal: :The international journal of neuropsychopharmacology 2016
Michaela-Elena Friedrich Elena Akimova Wolfgang Huf Anastasios Konstantinidis Konstantinos Papageorgiou Dietmar Winkler Sermin Toto Waldemar Greil Renate Grohmann Siegfried Kasper

BACKGROUND Drug-induced liver injury is a common cause of liver damage and the most frequent reason for withdrawal of a drug in the United States. The symptoms of drug-induced liver damage are extremely diverse, with some patients remaining asymptomatic. METHODS This observational study is based on data of Arzneimittelsicherheit in der Psychiatrie, a multicenter drug surveillance program in G...

Journal: :The Ceylon medical journal 2009
W K B Kasun Fernando P L Ariyananda

In many countries, paracetamol ranks at the top of all known poisoning agents implicated in accidental or intentional poisoning [1]. In general, liver injury caused by drugs is known to be either type A “dose dependent” (intrinsic toxicity) or type B idiosyncratic. Perhaps with the exception of single high dose of drug induced liver injury, most drug induced liver injury (DILI) cases evaluated ...

2016
Madison Davis Brendan D Stamper

In vitro models for hepatotoxicity can be useful tools to predict in vivo responses. In this review, we discuss the use of the transforming growth factor-α transgenic mouse hepatocyte (TAMH) cell line, which is an attractive model to study drug-induced liver injury due to its ability to retain a stable phenotype and express drug-metabolizing enzymes. Hepatotoxicity involves damage to the liver ...

Journal: :Hepatology 2014
Mark W Russo Jay H Hoofnagle Jiezhun Gu Robert J Fontana Huiman Barnhart David E Kleiner Naga Chalasani Herbert L Bonkovsky

UNLABELLED The HMG-CoA reductase inhibitors (statins) are widely prescribed for patients with hyperlipidemia and are generally well tolerated. Mild elevations in serum aminotransferases arise in up to 3% of treated patients, but clinically apparent drug-induced liver injury is rare. The aim of this study is to report the presenting features and outcomes of 22 patients with clinically apparent l...

Journal: :Advanced nanoBiomed research 2022

Drug-induced liver injury (DILI) is a significant cause of acute and remains major concern in drug discovery clinical use. Optical imaging, including fluorescence imaging photoacoustic has been widely used for the early accurate diagnosis DILI. Activatable optical probes can detect lesion-specific molecular alterations with high sensitivity signal-to-noise ratio, offering precise way to evaluat...

2014
Roxanne Lim Hassan Choudry Kim Conner Wikrom Karnsakul

Drug-induced hepatotoxicity most commonly manifests as an acute hepatitis syndrome and remains the leading cause of drug-induced death/mortality and the primary reason for withdrawal of drugs from the pharmaceutical market. We report a case of acute liver injury in a 12-year-old Hispanic boy, who received a series of five antibiotics (amoxicillin, ceftriaxone, vancomycin, ampicillin/sulbactam, ...

Journal: :Current opinion in allergy and clinical immunology 2006
José V Castell Marta Castell

PURPOSE OF REVIEW To examine recent advances in our understanding of how drugs can trigger a hypersensitivity reaction in the liver, how tolerance is lost, the mechanisms of damage to hepatocytes and the strategies towards a better assessment of an idiosyncratic drug liver reaction. RECENT FINDINGS Formation and presentation of drug-protein adducts, or a direct interaction with the major hist...

Journal: :Alimentary Pharmacology & Therapeutics 2012

Journal: :International Journal of Molecular Sciences 2018

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