OBJECTIVE We examined serum in patients of liver injury to explore the possible clinical application of abnormal micrometabolites as a marker of liver injury and severity in cases of traumatic liver damage. METHODS Serum were screened by proton nuclear magnetic resonance spectroscopy in 96 patients with varying degree of liver injury and compared with concentrations in healthy control volunte...

introduction  insulin-like growth factor i (igf-i) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. igf-i plays the roles via the receptor (igf-ir) signaling pathway. igf-ir unlike igf-i is expressed strongly in the developing liver, but much more weakly in adults. objective:  we hypothesiz...

objective: to evaluate the efficacy of modified perihepatic packing (mphp) in reducing the rate of re-bleeding rate after packing removal. methods: this was an experimental study being performed in shiraz animal laboratory. high grade liver parenchymal injury was induced in 30 transgenic australian rabbits which were then divided into two groups. group a (control) included 14 and group b (exper...

Background: Liver ischemia / reperfusion Injury (IRI) is one of the major causes of liver failure during various types of liver surgery, trauma and infections. The present study investigates the effect of dexsamethasone on the liver injury and inducible nitric oxide synthase gene expression during hepatic warm ischemia/reperfusion in rats. Materials and Methods: 24 male Wistar rats (200-250 g)...

This book is the latest edition of the series which report verbatim the papers presented at the annual meetings of small groups of competent investigators in a variety of medical fields. Informality and theorizing aloud are the keynotes, and account for much of the book's value and great readability. The names of the participants are well known in the field of medicine -F. W. Hoffbauer, Cecil J...

oxygen is an essential part of the most important metabolic pathways in aerobic organisms. oxygen delivery is merely dependent on blood, rendering blood loss a devastating event. traumatic pre-hospital liver bleeding is a major cause of early trauma deaths in human and animals, with no established therapeutic method yet. increasing intra-abdominal pressure (iap) has been shown to reduce liver b...

Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase ...