the present study appraised the hepatoprotective activity of aqueous extract of camellia sinensis leaves and its possible mechanism of action against carbon-tetrachloride-induced liver damage. liver damage was induced by   intraperitoneal administration of equal mixture of carbon tetrachloride   and olive oil (50 % v/v, 0.5 ml/kg ) in male wistar rats (150-220g) once daily for 7 days and the ex...

  SUMMARY Scolicidal agents are used by most surgeons during operations for hydatid cysts when these agents are injected into the cys t cavity, they can pass through the communicating passages between the cyst and bile ducts into the large intrahepatic and extrahepatic bile ducts and because of their caustic nature, they have the potential to damage the epithelium of ducts. This epithelial da...

Background: Stearic acid is known as a potent anti-inflammatory lipid. This fatty acid has profound and diverse effects on liver metabolism. The aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (APAP)-induced liver damage. Methods: Wistar rats were randomly assigned to 10-day treatment. Stearic acid was administe...

Tamoxifen in the treatment of metastatic carcinoma of the breast is usually well tolerated with few side effects.' 2 We report on a patient in whom tamoxifen was associated with deterioration of liver function. Case report A 75 year old woman, who had undergone radical mastectomy in 1978 for breast carcinoma, developed bony metastases by April 1982 and was treated with tamoxifen 10 mg twice dai...

Chronic heavy drinking can cause the liver to become fatty. Fat deposits in the liver block the liver cells from their blood supply, depriving them of oxygen and other nutrients, eventually killing them. As the name implies, the liver performs so many vital functions that we cannot live without it. The liver filters all of the blood in our bodies, breaking down and eliminating toxins, convertin...

Halothane was first synthesized by Suckling in 1952 and introduced into clinical practice a few years later.',2 Its many advantages, such as quick action, easy administration, non-explosiveness, high potency and low cost, led to its widespread use within a short time. Although initial animal work did not indicate any hepatotoxic effect,3`5 the first cases of unexplained hepatitis after exposure...

The association of aicohol with cirrhosis was recognised by~vfatthew Ba-ilhe4& 1793 and later by Addison. In Western countries the incidence of cirrhosis canbe directly related to the quantity of aicohol consumed. In France, between—1941 and 1947, rationing of wine from five to one litre per week led to an 80% reduction in mortaiity from cirrhosis (1). Cirrhosis is on the increase. In the U.S.A...

The Medical Assessor to the Committee on Safety ofMedicines recently issued' a letter entitled "Jaundice following repeated exposure to halothane," in which he noted that 130 reports of jaundice following anaesthesia had been received by the committee between 1964 and 1972, every case being associated with the use of halothane. Ninety-four of these patients had been exposed to halothane more th...