objective(s): the role of aluminum (al) in the pathogenesis of neurodegenerative diseases has been implicated in several studies. however, the exact mechanisms of cytotoxic effects of al have not been elucidated yet. the aim of this study was to investigate the effect of l-type calcium channel antagonist, nimodipine (nm), and lithium chloride (licl) on al-induced toxicity in pc12 cells. materia...

background the development of drug delivery systems has improved the therapeutic and toxic properties of existing drugs in therapy. microemulsion systems are novel vehicles for drug delivery, which have been developed in recent years. these systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating ...

lithium and valproate modulate disturbances in intracellular calcium homeostasis implicated in the pathophysiology of bipolar disorder, but the molecular mechanisms are not fully understood. two subtypes of transient receptor potential (trp) channel family, i.e. trpc3 and trpm2, are potential candidates involved in calcium signaling and implicated in the pathophysiology of bipolar disorder. thi...

one of the most important and serious disorders of gastrointestinal tract is acute pancreatitis which in severe form is associated with high mortality rate particularly in the presence of systemic inflammatory response and multiple organ failure. apoptosis linked to oxidative stress has been shown in the pancreas of the patients with acute pancreatitis. lithium, one of the most effective drugs ...

Lithium metal has shown great promise as an anode material for high-energy storage systems, owing to its high theoretical specific capacity and low negative electrochemical potential. Unfortunately, uncontrolled dendritic and mossy lithium growth, as well as electrolyte decomposition inherent in lithium metal-based batteries, cause safety issues and low Coulombic efficiency. Here we demonstrate...

background lithium is a drug for treatment of bipolar disorder by correcting mania and reducing depressive mood swings. objectives in this study, effects of lithium on volumetric parameters of cerebellum were investigated using stereological methods. materials and methods in this experimental study, 20 sexually mature wistar male rats were selected and divided in two groups randomly (n = 10). a...

background: therapeutic effects of lithium in manic-depressive disorders have been clarified. during the present study, the effects of lithium carbonate have been assessed on apomorphine-induced sniffing in rats. materials and methods: male albino rats were housed in a glass cylinder and food and water were freely available till 60 minutes before the experiment. immediately after apomorphine in...

BACKGROUND Lithium has been the gold standard in treating bipolar disorder. In recent years, the use of lithium seems to be diminished although it is well tolerated among the bipolar disorder patients. SUBJECTS AND METHODS This study aimed to evaluate the efficacy and tolerability of lithium as well as to determine factors associated with lithium response among patient with bipolar disorder. ...