نتایج جستجو برای: lisinopril

تعداد نتایج: 1071  

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2001
F S Ramalho L N Ramalho O Castro-E-Silva Júnior S Zucoloto F M Corrêa

Bradykinin has been reported to act as a growth factor for fibroblasts, mesangial cells and keratinocytes. Recently, we reported that bradykinin augments liver regeneration after partial hepatectomy in rats. Angiotensin-converting enzyme (ACE) is also a powerful bradykinin-degrading enzyme. We have investigated the effect of ACE inhibition by lisinopril on liver regeneration after partial hepat...

Journal: :Postgraduate medical journal 2000
M U Naidu P R Usha T R Rao J C Shobha

Angiotensin converting enzyme (ACE) inhibitors and dihydropyridine calcium antagonists are well established and widely used as monotherapy in patients with mild to moderate essential hypertension. Earlier studies combining short acting drugs from these classes require multiple dosing and were associated with poor compliance. Availability of longer acting compounds allows once daily administrati...

2014
B. Prathap Srinivasa Rao

A simple, specific, precise, and accurate reversed-phase HPLC method was developed and validated for simultaneous estimation of lisinopril and amlodipine besylate in tablet dosage forms. The separation was achieved by Hypersil ODS-BP C18 column (250 mm × 4.6 mm; 5.0 μm) using methanol: phosphate buffer at pH 6 adjusted with orthophosphoric acid (30: 70, v/v) as eluent, at a flow rate of 1 mL/mi...

Journal: :Diabetes care 2000
L Tarnow P Rossing C Jensen B V Hansen H H Parving

OBJECTIVE To compare the long-term effect on kidney function of a long-acting calcium antagonist (nisoldipine) versus a long-acting ACE inhibitor (lisinopril) in hypertensive type 1 diabetic patients with diabetic nephropathy. RESEARCH DESIGN AND METHODS We performed a 4-year prospective, randomized, double-dummy controlled study comparing nisoldipine (20-40 mg once a day) with lisinopril (10...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014
Rajiv Agarwal Arjun D Sinha Maria K Pappas Terri N Abraham Getachew G Tegegne

BACKGROUND The purpose of this study was to determine among maintenance hemodialysis patients with echocardiographic left ventricular hypertrophy and hypertension whether in comparison with a β-blocker-based antihypertensive therapy, an angiotensin converting enzyme-inhibitor-based antihypertensive therapy causes a greater regression of left ventricular hypertrophy. METHODS Subjects were rand...

Journal: :Bioorganic & medicinal chemistry letters 2006
Aloysius T Nchinda Kelly Chibale Pierre Redelinghuys Edward D Sturrock

With a view to developing a more C-domain-selective angiotensin I-converting enzyme (ACE)-inhibitor, a novel analogue of lisinopril has been synthesized which incorporates a bulky P(2)(') tryptophan functionality. This inhibitor demonstrated a significantly increased specificity for the C-domain as compared with lisinopril. Molecular docking revealed hydrophobic and hydrogen-bonding interaction...

Journal: :Journal of the American Society of Nephrology : JASN 2003
Ariela Benigni Carla Zoja Daniela Corna Cristina Zatelli Sara Conti Marco Campana Elena Gagliardini Daniela Rottoli Cristina Zanchi Mauro Abbate Steve Ledbetter Giuseppe Remuzzi

Renin-angiotensin system (RAS) inhibitors are effective in reducing renal disease progression in early diabetic nephropathy, but they provide imperfect protection at a later stage. Due to the pivotal role of transforming growth factor-beta (TGF-beta) in the pathogenesis of diabetic kidney disease, this study tested the effect of simultaneously interrupting TGF-beta and angiotensin II on disease...

Journal: :Hypertension 2006
Frans H H Leenen Chuke E Nwachuku Henry R Black William C Cushman Barry R Davis Lara M Simpson Michael H Alderman Steven A Atlas Jan N Basile Aloysius B Cuyjet Richard Dart James V Felicetta Richard H Grimm L Julian Haywood Syed Z A Jafri Michael A Proschan Udho Thadani Paul K Whelton Jackson T Wright

The Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) provides a unique opportunity to compare the long-term relative safety and efficacy of angiotensin-converting enzyme inhibitor and calcium channel blocker-initiated therapy in older hypertensive individuals. Patients were randomized to amlodipine (n=9048) or lisinopril (n=9054). The primary outcome was comb...

2007
Gülten TAÇOY Murat ÖZDEMIR Yusuf TAVIL Sedat TÜRKOGLU Atiye ÇENGEL

Gülten TAÇOY, Murat ÖZDEMIR, Yusuf TAVIL, Sedat TÜRKOGLU, Atiye ÇENGEL Gazi Üniversity Medical Faculty, Department of Cardiology, Ankara. SUMMARY Purpose: Afterload reduction decreases volume overload on the left ventricle in chronic asymptomatic aortic regurgitation (AR). In this prospective, randomized trial, we aimed to compare the effects of a 6-months long treatment with lisinopril versus ...

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