The action of choline and methionine in preventing or curing the fatty infiltration of the liver which is produced experimentally in animals by low protein diets is believed to result from an increased turnover of phospholipides in the liver (1, 2). Since this organ is the main, if not the sole, source of phospholipides in plasma (3), it would seem that changes in the formation of phospholipide...

Choline plays a lipotropic role in lipid metabolism as an essential nutrient. In this study, we investigated the effects of choline (5, 35 and 70 μM) on DNA methylation modifications, mRNA expression of the critical genes and their enzyme activities involved in hepatic lipid metabolism, mitochondrial membrane potential (Δψm) and glutathione peroxidase (GSH-Px) in C3A cells exposed to excessive ...

The excessive deposition of liver lipids which is produced in rats by feeding diets containing cholesterol is inhibited by choline and betaine (Best & Ridout, 1933; Best, Channon & Ridout, 1934). Choline was shown to affect both glycerides and cholesteryl esters but deposition of the former was inhibited more than that of the latter. .Many preventive and curative experiments were subsequently r...

body but rather that both ethyl trichloroand trifluoro-acetate are effective as lipotropic agents because of the CC13 or CF3 group. These groups are larger than the CH3 group and may exert their effects through a steric blockage of an enzyme system. Ethyl dichloroacetate was not only without lipotropic action but was highly toxic when given to rats in an established choline-deficient state. Rat...

In the accompanying paper (1) it is reported that rats maintained on a diet rnargiI~ in lipotropic activity developed fatty infiltration and fibrosis of the liver when given 15 per cent alcohol in lieu of drinking water or an isocaloric equivalent of sucrose over a period of 7 months. Since the hepatic changes could be prevented by supplementing the diet with choline or methionine, the possibil...

T HE DISCOVERY of the lipotropic action of choline, inositol and other substances1-led several workers to postulate their utility in the prophylaxis and therapy of both experimental and clinical atherosclerosis. It was reasoned that these factors might influence the deposition of lipids in the vascular wall, as well as in the liver. It was also suggested that they might affect the concentration...

Fatty liver syndrome or hepatic lipidosis (HL) is a condition thought to contribute to an increased incidence of peripartum disease, reduced response to therapy and decreased fertility in dairy cows. This syndrome is characterized by excess triglyceride (TG) accumulation in the liver and apparent decreased hepatic lipoprotein output. In lactating rats, a similar condition results from feeding a...

-In rats, the acute oral LDs0 value of neutralized 2-N-monoethylaminoethanol (MEAE) was found to be 1 "0 (0.68-1 35) g/kg. The acute oral toxicity of MEAE, but not that of 2-N-diethylammoethanol (DEAE) could be largely reversed by simultaneous or subsequent ingestion of choline. MEAE partially prevented the development of fatty hver in chohnedeficmnt rats. No reversal of depressed growth rate w...