Isoflavones are secondary phenolic metabolites found in most legumes. These compounds have important pharmacological significance such as anti-osteoporosis, anti-aging, and anti-cancer properties. Breast cancer is one of the common cancers women worldwide. Human epidermal growth factor receptor-2 (HER2) an target breast treatment. In this study, we evaluated ability sixty isoflavones to inhibit...

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis infection that attacks the lungs. a dangerous can cause death. In overcoming it, safe and effective treatment needed so this be cured. The purpose of study was to determine potential activity active compounds derived from xanthones contained in mangosteen rind as inhibitor protein with comparison compound Isoniazid. used...

The global pandemic of COVID-19 has caused disastrous consequences for both humans and the economy. purpose this study was to determine potential juwet (Syzygium cumini L.) moringa (Moringa oleifera as inhibitors RBD spike, helicase, Mpro, RdRp activity SARS-CoV-2 with an in-silico approach. Samples were obtained from PubChem RSCB PDB databases. drug similarity analysis determined using Swiss A...

Cancer is defined as a disease caused by progressive and abnormal cell proliferation in the body. This condition deoxyribonucleic acid (DNA) changes, which causes cells to lose their normal function. The aim of this study find that flavonoid compounds have more stable interaction than tamoxifen anti-cancer candidates. Research has been conducted silico with molecular docking (AutodockTools-1.5....

THE USE OF FREE SOFTWARES IN PRACTICAL CLASS ABOUT MOLECULAR FILTERS ORAL BIOAVAILABILITY DRUGS. The study of the physical chemical properties to predict oral bioavailability drugs is a widely tool used by researches on Pharmaceutical and Medicinal Chemistry field. Even though it deeply studied subject, complex task teach pharmacy students. Lipinski stablished that molecular weight, lipophilici...

Leukemia Limfoblastik Akut (LLA) merupakan penyakit hematologi heterogen yang ditandai dengan proliferasi sel limfoid imatur di sumsum tulang, darah tepi, dan organ lainnya karena adanya mutasi pada reseptor JAK. Beberapa tahun terakhir, strategi baru menargetkan protein terkait untuk degradasi seperti Proteolysis targeting chimerics (PROTAC) diteliti. Penelitian ini bertujuan studi in silico a...

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as they display vast biological activities. Recent efforts concerning preparation oxindole using isatin-based multicomponent reactions (MCRs) constitute a advance generating druglike libraries fast and with wide scaffold diversity. In this review, we address those recent developments, exploring syntheti...

Alkaptonuria is an inherited disease that is caused by homogenticate accumulation. Deficiency or mutation in Homogentisate 1,2 dioxygenase gene (chromosome 3q21-q23) leads to production of incorrectly folded or truncated enzyme. Several studies indicated that competitive inhibitors of Homogentisate 1,2 dioxygenase like Nitisinone could be used for Alkaptonuria treatment. Therefore, it is of int...

In our endeavor towards the development of potent anticancer agents, two different sets of biphenylurea-indolinone conjugates, 5a-s and 8a,b were synthesized. The in vitro cytotoxicity of the synthesized compounds was examined in two human cancer cell lines, namely MCF-7 breast cancer and PC-3 prostate cancer cells using the sulforhodamine B (SRB) colorimetric assay. In particular, the MCF-7 ca...