نتایج جستجو برای: lipa protein
تعداد نتایج: 1235146 فیلتر نتایج به سال:
Genome-wide association studies (GWASs) have identified multiple coronary artery disease (CAD) risk loci, yet moving from association to mechanistic insights and therapeutic translation remains a major challenge. Several GWASs have identified LIPA as a novel locus for CAD. LIPA encodes lysosomal acid lipase (LAL), the major lysosomal enzyme hydrolyzing cholesteryl esters (CEs) and triglycerides...
We report the isolation and genetic characterization of novel Tn10dTc and Tn1000dKn insertion mutations in and near the lip locus of the Escherichia coli chromosome. The Tn10dTc and Tn1000dKn mutations define two genes, lipA and lipB, involved in lipoic acid biosynthesis. Two representative alleles (lip-2 and lip-9) from the previously reported genetic class of lipoic acid auxotrophic mutants (...
Objective: We previously reported smooth muscle cells (SMCs) represent ?50% of foam in human coronary and ?70% apoE (apolipoprotein E)-deficient mouse aortic atheromas exhibit reduced expression the cholesterol exporter ABCA1 (ATP-binding cassette transporter A1). A major stimulus for is flux out lysosomes, generated by hydrolysis lipoprotein cholesteryl esters LAL (lysosomal acid lipase). In t...
BACKGROUND Transcatheter arterial chemoembolization is a common treatment for patients with inoperable hepatocellular carcinoma. If the carcinoma is advanced or the main arterial supply, the hepatic artery, is occluded, extrahepatic collateral arteries may develop. Both, right and left inferior phrenic arteries (RIPA and LIPA) are the most frequent and important among these collaterals. However...
Background: Although moderate-to-vigorous physical activity (MVPA) is mainly recommended for glucose control, light physical activity (LIPA) may also have the potential to induce favorable changes. We investigated sedentary time (SED) substitution with equal time in LIPA and MVPA, and the association with markers of glucose regulation and insulin sensitivity after stratification by waist circum...
BACKGROUND eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). METHODS AND RESULTS In a genome-wide association analysis of 2078 CAD cases and 2953 control subjects, we identified 950 single...
We evaluated a new line probe assay (LiPA) kit to identify Mycobacterium species and to detect mutations related to drug resistance in Mycobacterium tuberculosis. A total of 554 clinical isolates of Mycobacterium tuberculosis (n = 316), Mycobacterium avium (n = 71), Mycobacterium intracellulare (n = 51), Mycobacterium kansasii (n = 54), and other Mycobacterium species (n = 62) were tested with ...
To offer location-based services, service providers need to have access to Location Information (LI) regarding the users which they wish to serve; this is a potential privacy threat. Constraints, i.e. statements limiting the use and distribution of LI, that are securely bound to the LI, have been proposed as a means to reduce this threat. However, constraints may themselves reveal information t...
Sensitive and early detection of emerging hepatitis B virus (HBV) drug resistance may not only help monitor the viral dynamics associated with lamivudine treatment but could also improve therapeutic decision making. This is especially important when new antivirals effective against lamivudine-resistant HBV become available. A total of 159 serum samples from 33 chronic HBV patients receiving lam...
A reverse hybridization test (Inno-LiPA HCV; Innogenetics, N.V., Zwijnaarde, Belgium) was used for typing hepatitis C virus. All 38 samples, typed by PCR with primers from core and NS5 genes, were also genotyped by this test. Of the samples, 33 (87%) had the same subtypes by both assays. The correlations between PCR and Inno-LiPA for individual types were 77% for type I (1a), 90% for type II (1...
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