INTRODUCTION It has long been recognized that anxiety symptoms and syndromes may be caused by medication and/or substance of abuse. The aim of this report is to present a patient who experienced social phobia following maprotiline, an adverse drug reaction which has not been reported previously with this agent. CASE PRESENTATION A 27 year-old male patient was suffering from dysthymia for 6 ye...

Elevating GABA levels in the synaptic cleft by inhibiting its reuptake carrier GAT1 is an established approach for the treatment of CNS disorders like epilepsy. With the increasing availability of crystal structures of transmembrane transporters, structure-based approaches to elucidate the molecular basis of ligand-transporter interaction also become feasible. Experimental data guided docking o...

ƒÊg per 100ml plasma, respectively. Mean normal fT3 and fT4, calculated from tT3, tT4 and EF values of T3 and T4, were 2.43 and 2.21mƒÊg per 100ml plasma, respectively. The fT3 values can be obtained by the present method more easily and speedily than by the method of Nauman et al. The present fT4 values, in con sideration of BEI and the percentage of T4 in plasma, represent a more accurate one...

Certain differences between phage T3 on the one hand and T3sam- and T7 on the other hand indicate that the T3-coded SAMase function is responsible (i) for the development of the pseudolysogenic state by preventing T3 DNA methylation, and (ii) for the partial protection of the phage DNA against restriction by the P system.