Background— -Linolenic acid may protect against cardiovascular disease. We examined the association between adipose tissue -linolenic acid and nonfatal acute myocardial infarction (MI) in a population-based case-control study in Costa Rica. Methods and Results—The 482 case patients with a first nonfatal acute MI and 482 population control subjects were matched by age, sex, and area of residence...

Inhibition of Ehrlich ascites carcinoma respiration by aqueous extracts of oxidized linoleic or linolenic acid (aqueous emulsions UV-irradiated, 90 min) was associated entirely with relatively involatile compounds which were both thiobarbituric acid (TBA)-reactive and peroxidase-reactive. Inhibitory compounds were heat stable and migrated in thin-layer chromatography with aldehydes, "hydroperox...

In the time period of 1994-1998, a case-control study on diet and prostate cancer was carried out in Uruguay to examine the risk associated with fat intake. Two hundred and seventeen (217) incident cases afflicted with advanced prostate cancer were frequency-matched with 431 controls on age, residence, and urban/rural status. The analysis was carried out using unconditional multiple logistic re...

I. In Expt I , four adult wether sheep were given diets of hay or dried grass in an alternating sequence of feeding treatments. Each treatment period lasted for 20 days and blood samples were taken from the sheep on the last day of each period. When the diet of hay (linoleic: linolenic acid ratio 1.40) was replaced by one of dried grass (1inoleic:linoltnic acid ratio 0.28), there was an increas...

The effect of linolenic acid on photosynthetic electron transport reactions in chloroplasts has been localized at a site on the donor side of photosystem I and at two functionally distinct sites in photosystem II.In photosystem I, an increase in the electron transport rate occurs in the presence of 10 to 100 micromolar linolenic acid, followed by a decline in rate from 100 to 200 micromolar lin...

The aim of this study was to compare the impact of dietary supplementation with a Bifidobacterium breve strain together with linoleic acid & α-linolenic acid, for 7 weeks, on colonic sensitivity and fatty acid metabolism in rats. Maternally separated and non-maternally separated Sprague Dawley rats (n = 15) were orally gavaged with either B. breve DPC6330 (10(9) microorganisms/day) alone or in ...

Essential fatty acids (EFAs) can be defined by classic definition, which defines EFAs as the fatty acids that are required for proper functioning of cells, but the body cannot synthesize them and, therefore, must be supplied by diet. According to this definition, there are only two EFAs: linolenic acid (LA, C18:2, n-6) and alpha-linolenic acid (ALA, C18:3, n-3). The functional definition of EFA...

85. Arnold, L. E., Kleykamp, D., Votolato, N. A., Taylor, W. A., Kontras, S. B., and Tobin, K. Gamma-linolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamine. Biol.Psychiatry 1-151989;25(2):222-228. View urgess, J. R. other disruptive behaviors. Lipids 2003;38(10):100786. Stevens, L., Zhang, W., Peck, L., Kuczek, T., Grevstad, N., Mahon, A., Ze...

Background— -Linolenic acid, an intermediate-chain n-3 fatty acid found primarily in plants, may decrease the risk of fatal coronary heart disease (CHD) through a reduction in fatal ventricular arrhythmias and sudden cardiac death (SCD). Methods and Results—We prospectively examined the association between dietary intake of -linolenic acid assessed via updated food-frequency questionnaires and ...

The transfer of fatty acids across biological membranes is a largely uncharacterized process, although it is essential at membranes of several higher plant organelles like chloroplasts, peroxisomes, or the endoplasmic reticulum. Here, we analyzed loss-of-function mutants of the unicellular cyanobacterium Synechocystis sp. PCC 6803 as a model system to circumvent redundancy problems encountered ...