background:   objective: in this study we performed linkage analysis on a large x linked rsa pedigree to find a novel susceptibility locus for rsa.   materials and methods: a linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary x-linked rsa. two point parametric linkage was performed using superlink v 1.6 program. results: evidence of linkage was o...

OBJECTIVE: To study the feasibility of making an early diagnosis of adult polycystic kidney disease by using genetic linkage analysis in Hong Kong. DESIGN: Genetic linkage study. SETTING: University teaching hospital, Hong Kong. PARTICIPANTS: Six members of a Chinese family with a history of adult polycystic kidney disease. MAIN OUTCOME MEASURES: The inheritance pattern of adult polycystic kidn...

parkinson’s disease (pd) is a prevalent neurodegenerative disease that usually affects individuals over 50 years of age. age at onset in a small subset of pd cases is considerably lower, and these are considered early-onset pd (eopd) patients. most pd cases appear sporadic, but approximately 15% are familial, and some of the familial cases exhibit mendelian inheritance. genetic analysis of fami...

hemophagocytic lymphohistiocytosis (hlh) is one of the complications of epstein-barr virus (ebv) infection. although the patients who have developed hlh following ebv have normal immune system, there are a few patients with ebv-induced immune deficiency who develop hlh as well. here, we describe the case of a 10-year-old girl with neurological complications caused by ebv-induced hlh. the patien...

background: the study of the association between genotype and phenotype is of great importance for the prediction of many diseases and pathophysiological conditions. the relationship between angiotensin-converting enzyme (ace) gene insertion/ deletion (i/d) polymorphism and pathological processes such as coronary artery disease (cad) has been investigated previously with discordant results. thi...

tagging of restorer genes for wild abortive (wa) of cytoplasmic male sterility was carried out by studying 10000 individuals from an f2 population of a cross between ir58025a × ir42686r. this study was primarily carried out to reduce the distance of the already known markers for rf gene. this f2 population was identified to be unique as four rf genes could be tagged to ssr markers on chromosome...