The yycF1(Ts) mutation in Staphylococcus aureus conferred hypersensitivity to macrolide-lincosamide-streptogramin B (MLS(B)) antibiotics on strains either containing or lacking ermB. The overexpression of the S. aureus Ssa protein restored the yycF1 mutant to wild-type levels of susceptibility. Inactivation of ssa in an unmutagenized strain dramatically reduced ermB-based resistance. Conditiona...

The objective of this study was to evaluate the clinical outcomes and safety clindamycin combination antibiotherapy for treatment erythromycin-resistant, lincosamide-susceptible bone joint infections caused by Staphylococcus spp. Between January 2010 September 2018, 46 patients with were treated 6 12 weeks. type infection prosthetic in 20 cases (43.5%), osteosynthetic device 15 (32.6%), chronic...

background staphylococcus aureus is a common pathogen in hospitals and communities. antibiotic resistance is a major public health problem. objectives the aim of this study was the determination of antimicrobial susceptibility patterns and to perform molecular detection of macrolide and lincosamide-resistance genes in clinical s. aureus isolates from kerman, iran. conclusions a high prevalence ...

In 540 beta-hemolytic streptococci, the rates of resistance to tetracycline, chloramphenicol, erythromycin, and clindamycin were 80.0, 22.8, 20.2, and 19.1%, respectively. Of the erythromycin-resistant isolates, 63.3% had the constitutive macrolide-lincosamide-streptogramin B (MLSB) resistance phenotype, 23.9% had the M phenotype, and 12.8% had the inducible MLSB resistance phenotype. The const...

In 540 beta-hemolytic streptococci, the rates of resistance to tetracycline, chloramphenicol, erythromycin, and clindamycin were 80.0, 22.8, 20.2, and 19.1%, respectively. Of the erythromycin-resistant isolates, 63.3% had the constitutive macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotype, 23.9% had the M phenotype, and 12.8% had the inducible MLS(B) resistance phenotype. The c...

Clindamycin, a lincosamide antibiotic, has been under-recognized as an antimicrobial agent for use in dentistry. The aim of the present work was to evaluate clinical efficacy of 2% clindamycin gel in addition to the basic mechanical periodontal therapy. At baseline, scaling and root planing (SRP) was performed at all 50 subjects (control group and test group). Clindamycin gel was applied after ...

AIM The aims of the present study were to determine the antibiotic susceptibility profils with particular emphasis on susceptible or resistant strains to macrolides and lincosamids antibiotics and to determine possible antibiotic resistance mechanisms occurring in group B streptococci (GBS) strains using PCR assay and disk diffusion method. METHODS A total of 62 clinical GBS strains were inve...