We have previously shown that frontoparietal scleroderma en coup de sabre, a type of linear scleroderma that affects the face and scalp, follows the lines of Blaschko, but the question whether linear scleroderma that occurs in the limbs follows Blaschko's lines has not been answered. We describe the case of a 4-year-old girl with multiple morphea showing remarkable unilateral systematized distr...

Introduction. Systemic sclerosis is a rare autoimmune disorder of the connective tissue, gastrointestinal tract, lungs, kidneys, and musculoskeletal tissue. It predominantly affects women. The localized variant limited scleroderma. Case Report. We present 64-year-old female patient with diagnosis scleroderma that has lasted for thirteen years. She had hyperpigmentation, telangiectasias, progres...

INTRODUCTION Treprostinil diethanolamine is an innovative salt form of the prostacyclin analogue, treprostinil sodium, developed as an oral sustained release (SR) osmotic tablet. The availability of a formulation permitting convenient systemic delivery might have applicability to scleroderma vascular complications. We evaluated pharmacokinetics and perfusion in scleroderma patients with digital...

Connective tissue diseases (CTDs) are a group of clinical disorders that have an underlying autoimmune pathogenesis. These include a diverse set of diseases such as relapsing polychondritis, rheumatoid arthritis, and eosinophilic fasciitis, along with more common entities like Sjogren's syndrome, dermatomyositis, scleroderma, and lupus erythematosus. The latter three will be the focus of this r...

Scleroderma is a rare condition, occurring most commonly in females, the onset of which is usually heralded by Raynaud's phenomenon, cutaneous sclerosis, or arthritic symptoms. General constitutional disturbances such as lassitude, anorexia, and weight loss are common. The course of the disease may be prolonged, or death may supervene within a year of onset. No part of the body appears to be im...

Cutaneous ulcerations may be due to a variety of causes, including vasculitis, infections, arterial insufficiency, and microvascular damage. The net effect is diminished blood flow to the skin. Nifedipine, a calcium antagonist, has been shown to improve cutaneous blood flow and to alleviate reactive vasospastic ischemia (Raynaud's phenomenon). The authors report an ischemic ulcer of scleroderma...

Three patients presented with septal fasciitis and panniculitis, associated with clinical and laboratory features which precluded straight-forward classification into eosinophilic fasciitis, localised scleroderma, or lupus erythematosus profundus. Treatment with cimetidine caused the remission of cutaneous manifestations and the extracutaneous abnormalities, such as nailfold capillary disturban...

Systemic sclerosis sine scleroderma is a rare form of limited systemic sclerosis. These patients are without skin involvement, but do not differ in its clinical or laboratory features and prognosis from classical systemic sclerosis. In the absence of cutaneous signs/symptoms, its diagnosis is delayed leading to significant morbidity and mortality. We report a case of sixty year old female who p...

INTRODUCTION Cutaneous metastasis is an uncommon manifestation of internal malignancy. The rate of cutaneous metastasis in ovarian cancer is 3.5%, andmedian time of survival after appearance of cutaneous metastasis is 4 months. The lesions involved are often described as flesh colored, pink, or violaceous cutaneous or subcutaneous nodules, although reports of non-nodular metastases exist. We re...