Differential microarray experiments have shown that there are 186 transcripts predominantly overexpressed in the limbus, 644 in the cornea and 506 in the conjunctiva of the vervet monkey. In humans, 332 and 592 transcripts are predominantly overexpressed in the conjunctival and corneal epithelia, respectively. Mounting evidence generated from clinical observations and experimental animal studie...

Introduction ALTHOUGH the cornea normally has no blood vessels, yet, under certain conditions, new vessels freely enter the substa-nce of the cornea from the limbal plexus. To explain this invasion many theories have been advanced. In riboflavin deficiency there is corneal vascularization. Since riboflavin is part of an oxidation enzyme system, Bessey and Wolbach (1939), and Johnson and Eckardt...

Histological and electron microscopic observations, together with virus cultures, were made in the eyes of 50 New Zealand white rabbits which received bilateral intrastromal inoculation with the RE strain of herpes simplex virus. Virus cultures of whole corneas were positive for the first 2 weeks following inoculation, but were consisently negative thereafter. An inflammatory response to HSV in...

Introduction To evaluate the expression patterns of cytokeratin (K) 12, 13, and 19 in normal epithelium of the human ocular surface to determine whether K13 could be used as a marker for conjunctival epithelium. Methods: Total RNA was isolated from the human conjunctiva and central cornea. Those transcripts that had threefolds or higher expression levels in the conjunctiva than the cornea wer...

PURPOSE To correlate a biomicroscopic evaluation, an in vivo confocal microscopy examination, and impression cytologic findings of the corneal center and sclerocorneal limbus after cultured limbal stem cell transplantation and to test the effectiveness of in vivo confocal microscopy as a diagnostic procedure in ocular surface cell therapy reconstructive surgery. METHODS Six eyes of six patien...

Stem cells are present in all self-reviewing tissues and have unique properties. The ocular surface is made up of two distinct types of epithelial cells, constituting the conjunctival and the corneal epithelia. These epithelia are stratified, squamous and non-keratinized. Although anatomically continuous with each other at the corneoscleral limbus, the two cell phenotypes represent quite distin...

tides are seen in the in vivo experiment than in the in vitro one suggests that synthesis of polyglucose is regulated in the cell even under in vivo histochemical conditions. Another use of the enzyme-synthetic approach in the in vivo cornea has been shown in the present study. The number of synthesized polyglucose particles in the corneal epithelium indicates the amount of glucose-1-phosphate ...

PURPOSE The presence of antigen-presenting cells (APCs) such as Langerhans cells (LCs), an epithelial form of dendritic cells (DCs), in corneal tissue is critical for generation of immune responses, including graft rejection and herpetic keratitis. The purpose of this study was to characterize the distribution and major histocompatibility complex (MHC) antigen expression of corneal LCs. METHO...

tides are seen in the in vivo experiment than in the in vitro one suggests that synthesis of polyglucose is regulated in the cell even under in vivo histochemical conditions. Another use of the enzyme-synthetic approach in the in vivo cornea has been shown in the present study. The number of synthesized polyglucose particles in the corneal epithelium indicates the amount of glucose-1-phosphate ...

Material and Method: There were 120 cases aged between 30-60 years of both genders. Included patients had primary Pterygium encroaching cornea up to 2 mm from limbus. Patients with Pseudopterygium, recurrent Pterygium and active ocular infection were excluded. All the selected patients underwent limbal stem cell autograft technique for pterygium treatment and recurrence was noted after 6 months...