As the primary microtubule-organizing centers, centrosomes require gamma-tubulin for microtubule nucleation and organization. Located in close vicinity to centrosomes, the Golgi complex is another microtubule-organizing organelle in interphase cells. CDK5RAP2 is a gamma-tubulin complex-binding protein and functions in gamma-tubulin attachment to centrosomes. In this study, we find that CDK5RAP2...

We show an O∗(2k)-time polynomial space algorithm for the k-sized Graph Motif problem. We also introduce a new optimization variant of the problem, called Closest Graph Motif and solve it within the same time bound. The Closest Graph Motif problem encompasses several previously studied optimization variants, like Maximum Graph Motif, Min-Substitute, and Min-Add. Moreover, we provide a piece of ...

The DNA-protein interactions in the ETS2 promoter have been studied. Three distinct sequence motifs have been identified, each of which interacts with at least two distinctive protein complexes. The GC motif, possessing mirror symmetry, interacts with two ubiquitously identifiable complexes (S and S2); the PEA3 motif interacts with a ubiquitous (H1) and a tissue-specific (H3) complex; the H2 (a...

The apoptotic programme is evolutionarily conserved between yeast and metazoan organisms. We have previously identified a number of mammalian cDNAs capable of suppressing the deleterious effects of Bax expression in yeast. We herein report that one such suppressor, named Tsc22((86)), represents the C-terminal 86 amino acids of the previously characterized leucine zipper (LZ) motif-containing tr...

Koi herpesvirus (KHV) is responsible for high mortality in the common carp, a global food staple of which over 1.5 million metric tons is harvested annually. The objective of this study is to investigate B-DNA interactions with a hypothesized Zα, or Z-DNA binding, domain in the KHV open reading frame 112 (ORF112) peptide motif. Mutations analogous to the Y84A and N62D mutations have been shown ...