Most anaesthetists would agree that there is room for a more satisfactory intravenous anaesthetic than thiopentone. This drug is a powerful depressor both of blood pressure and of respiration. The compound G.29.505 was investigated in the laboratory by Thuillier and Domenjoz (1957), and appeared to offer some promise, particularly because of some tendency on its part to stimulate respiration. F...

Avoiding a hangover is a great goal to have! Many folks who participate in moderate or higherrisk drinking [2] experience a hangover at some point (though some people can experience a hangover with just one drink). A hangover isn't just one symptom; it's a set of possible symptoms a person may experience after consuming alcohol. With a bit of planning, symptoms of hangovers can be minimized whe...

The effects of a single 384 mg oral dose of chlormethiazole were compared with those of 20 mg of temazepam and placebo in healthy old and young women (mean ages 72.9 and 24.7 years respectively). Both drugs were effective hypnotics and had no detectable pharmacological action the next morning. Even four hours after administration performance of a simple psychomotor test was not impaired and swa...

The currently accepted explanation of the short action of barbiturate anesthetics is that the redistribution of drug within the body compartments and also some degree of metabolism being involved. It is, however manifestly evident that the barbiturates anesthetic are not rapidly metabolized. Thus it was assumed that molecular modifications could provide barbiturates which undergo rapid metaboli...

Daphne Du Maurier’s international bestseller, Rebecca, has always puzzled readers, reviewers, and critics alike. Often hard put to define why the novel them in its thrall what genre or category it can be said fall under, they resort explanations which are both numerically impressive strikingly contradictory. To underline exceptional singularity of such a work, unique literary historical status ...

www.ums.ac.uk The epilepsies are a common, heterogeneous group of disorders linked by a tendency to recurrent seizures in affected individuals and which have no respect for age, gender, race or social status. A seizure is defined as an intermittent, stereotyped, disturbance of consciousness, behaviour, emotion, motor function, or sensation that on clinical grounds is believed to result from cor...

Avoiding a hangover is a great goal to have! Many folks who participate in moderate or higherrisk drinking [2] experience a hangover at some point (though some people can experience a hangover with just one drink). A hangover isn't just one symptom; it's a set of possible symptoms a person may experience after consuming alcohol. With a bit of planning, symptoms of hangovers can be minimized whe...

In this study, the authors contribute insight into the temporal nature of work attitudes, examining how job satisfaction changes across the 1st year of employment for a sample of organizational newcomers. The authors examined factors related to job change (i.e., voluntary turnover, prior job satisfaction) and newcomer experiences (i.e., fulfillment of commitments, extent of socialization) that ...

OBJECTIVE The aim of this study was to compare performance measures after acute alcohol consumption (intoxication) with the performance the day after a normal night's drinking (hangover). METHODS Eighty-four social drinkers took part in two studies that followed a counterbalanced repeated measure design. Fifteen men and 33 women were tested the morning (09:00, 11:00 or 13:00 h) following norm...