A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective ...

sesamol is a sesame lignan. sesame lignans have multiple functions, including antioxidant activity and also seem to have potential as a source of phytostrogens. this study was condncted to evaluate sesamol contents of 7 brands of iranian sesame seeds (sesamum indicume l.). the brands were named karaj 29, darab 14, ultan, dezful, varamin, branching naz, and nonbranching naz. after method validat...

Elicitors could be used as the enhancer of plant secondary-metabolite synthesis and could play an important role in biosynthetic pathways of important medicinal compounds. The present study investigated the effect of abiotic elicitor (fungal extract of Fusarium graminearum) and two abiotic elicitors (methyl jasmonate and salicylic acid) at different concentrations in 18- and 30-day-old cultures...

Background & aim: Flaxseed is the richest source of lignan which is one of the main categories of phytoestrogens. In addition to the estrogenic and anti-estrogenic properties of lignan, it has non-hormonal properties as well. The treatment of menopausal hot flashes and cyclic mastalgia, the reduction in vasomotor symptoms and tumor cell growth and recurrence, the prevention of breast and ovaria...

Lignans are phenylpropane dimers that are biosynthesized via the phenylpropanoid pathway, in which pinoresinol lariciresinol reductase (PLR) catalyzes the last steps of lignan production. Our previous studies demonstrated that the contents of lignans in various wheat cultivars were significantly associated with anti-tumor activities in APC(Min) mice. To enhance lignan biosynthesis, this study w...

Near-infrared spectroscopy (NIRS) was used to develop a rapid and efficient method to determine lignan glucosides in intact seeds of sesame (Sesamum indicum L.) germplasm accessions in Korea. A total of 93 samples (about 2 g of intact seeds) were scanned in the reflectance mode of a scanning monochromator, and the reference values for lignan glucosides contents were measured by high performance...

Flaxseed, the richest source of mammalian lignan precursors, such as secoisolariciresinol diglycoside (SD), has been shown over the short term to decrease some early markers of colon cancer risk. This study determined whether over the long term flaxseed still exerts a colon cancer protective effect, whether its effect may, in part, be due to its high content of SD and whether any change in beta...