Background: Lewy body dementia is a common but frequently underdiagnosed cause of dementia often mistaken for the more familiar entity of Alzheimer disease. Clinically the distinction is important, because it can have profound implications for management. Methods: The medical literature was searched using the keywords “Lewy bodies,” “Lewy body dementia,” “Alzheimer dementia,” and “parkinsonian ...

Objectives: Electroencephalography can still reveal a variety of focal abnormalities in different neurological diseases. EEG could represent an easy and economical tool to differentiate parkinsonisms when compare to neuroradiological studies. We want to report the EEG findings in a serie of diffuse lewy body disease and demented Parkinson ́s disease patients of our unit of movement disorders, in...

OBJECTIVE To further elucidate the relation between diffuse Lewy body disease and Parkinson's disease. METHODS AND RESULTS The clinical features of nine cases of pure diffuse Lewy body disease without pathological evidence of coexisting Alzheimer's neuritic pathology were reported. All patients were aged less than 70 years at onset (mean 62 years). Five patients presented with clinical featur...

Lewy body disease is defined as Lewy body-related neuronal degeneration involving the nigrostriatal system, limbic-neocortical system, and peripheral autonomic nervous system (PANS). We investigated whether the adrenal gland, which is evolutionarily related to sympathetic ganglia and is routinely examined in general autopsy, could be used to assess pathology of the PANS in Lewy body disease. Br...

OBJECTIVE To evaluate the relative merits of recently developed criteria for dementia with Lewy bodies (DLBs) in a longitudinal study of dementia. DESIGN The diagnosis of DLBs was used in combination with other clinical diagnosis. Patients were classified primarily based on the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Rela...

The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic w...

Clinical dementia associated with the appearance of Lewy bodies in the cerebral cortex has been recognized for over 40 years. Until the 1990s, however, cortical Lewy body disease was thought to be a rare cause of dementia. At that time, the advent of sensitive and specific immunohistochemical techniques for highlighting these elusive structures led to the recognition of cortical Lewy body disea...

There is limited information on the validity of the pathologic criteria of the Third Consortium on Dementia with Lewy bodies (CDLB), and none are based on prospectively diagnosed cases. In this study, the core clinical features of dementia with Lewy bodies (DLB) and the suggestive clinical feature of rapid eye movement sleep behavior disorder were assessed using a battery of standardized clinic...

We impose various oracle mechanisms on nondeterministic pushdown automata, which naturally induce nondeterministic reducibilities among formal languages in a theory of context-free languages. In particular, we examine a notion of nondeterministic many-one CFL reducibility and conduct a ground work to formulate a coherent framework for further expositions. Two more powerful reducibilities— bound...