A role for the 0~4-integrin (OL4~ 1 o r 0t.4~7) , has been imphcated in the recruitment of peripheral blood mononuclear cells (PBMCs) to sites of inflammation. However, the adhesive interactions (i.e., tethering, rolling, and adhesion) mediated by the ot4-integrin have not been characterized in vivo. The objective of this study was to establish a model wherein postcapillary venules were chronic...

OBJECTIVE To find out the incidence of BCG-scar failure, in BCG vaccinated children and assess their in vitro cellular response. DESIGN Four year prospective cohort observational study. SETTING Immunization centers at: (a) State Tuberculosis Center; (b) Tuberculosis Association of Andhra Pradesh; and (c) Niloufer Hospital for Women and Children in Hyderabad. METHODS Healthy children broug...

kcnk2 was previously shown to regulate immune-cell trafficking into the central nervous system (cns). kcnk2-/- mice demonstrated a more severe disease course in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, due to an increased immune-cell migration into the cns. an upregulation of the cellular adhesion molecules icam1 and vcam1 on brain endothelial cells in k...

We had found previously that children with ragweed hay fever were somewhat less symptomatic after preseasonal immunization with large doses of ragweed pollen extract than were placebo-treated children. To study further the immunologic changes which accompany immunotherapy, these children were treated again the following year. Each patient served as his own control. Serum blocking (IgG) antibody...

Pseudomonas aeruginosa is an opportunistic pathogen which causes sight-threatening corneal infections in humans. The purpose of this study was to evaluate various immunization routes that may provide protection against Pseudomonas keratitis and to define the molecular mechanisms involved in the protection. Sprague-Dawley rats (10 to 12 weeks old) were immunized using paraformaldehyde-killed P. ...

A role for the alpha 4-integrin (alpha 4 beta 1 or alpha 4 beta 7), has been implicated in the recruitment of peripheral blood mononuclear cells (PBMCs) to sites of inflammation. However, the adhesive interactions (i.e., tethering, rolling, and adhesion) mediated by the alpha 4-integrin have not been characterized in vivo. The objective of this study was to establish a model wherein postcapilla...

This study was performed to define the correlation between the level of consciousness based on Glasgow coma scale ( GCS), Glasgow outcome scale( GOS) and leukocyte count. Two hundred and thirty three patients ( female: 48, male: 185) ranged between 1-75 years old were studied. The results showed that there was a negative correlation between increasing leukocyte count and  GCS ( n=233.r= .0.3, p...

background: miscarriage is a common phenomenon complicating more than half of pregnancies. recurrent pregnancy loss (rpl) is defined as three or more pregnancies lost before the twentieth week of gestation. it is believed that abnormality in maternal immune reaction to fetus and sharing of hla antigens might be associated with rpl. objective: to investigate the effect of hla-drb1 sharing betwee...

the leukotrienes and prostaglandins are biologically active metabolites derived from arachidonic acid. the leukotrienes have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowel disease and asthma. montelukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. the present study aimed to assess the role of cysteinyl leukotriene receptor a...

oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory process of bronchial asthma. reactive oxygen species are released into the bronchial tree by activated inflammatory cells. in this study, we aimed to determine the effect of vitamin c administration on leukocyte vitamin c level as well as severity of asthma. in this double blind clinical trial study ...