Sir, The development of melanocytic lesions following treatment with psoralen and ultraviolet A (PUVA therapy) is well documented. The first case of lentigines induced by cosmetic UVA tanning was reported in the 1980s (1), and another three cases have been published since then (2 – 5). We report the case of a woman with systemic lupus erythematosus (SLE) who developed generalized persistent mel...

LEOPARD syndrome (LS) is a congenital developmental disorder and is an acronym for multiple lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness (1). These clinical features overlap those of Noonan syndrome (NS), and heterozygous germline PTPN11 mutations have been ident...

Eruptive lentigines in the area of resolving psoriatic plaques has been well documented literature following successful treatment with multiple therapies. This is historically associated light but expanded to include other therapies such as anti-tumor necrosis factor and, more recently, some biologics5. Guselkumab (Tremfya) an IgG1λ monoclonal antibody used plaque psoriasis only one case erupti...

A sixteen year old girl presented with history of hemoptysis of one week duration. She had history of dyspnea on exertion and frequent respiratory infections in childhood. She had short stature, hypertelorism, neurofibroma, café au lait spots and multiple lentigines. She had features of severe pulmonary hypertension and differential clubbing and cyanosis. A final diagnosis of LEOPARD syndrome w...