نتایج جستجو برای: leigh disease
تعداد نتایج: 1491454 فیلتر نتایج به سال:
BackgroundVolatile anaesthetics are widely used in human medicine. Although generally safe, hypersensitivity and toxicity can occur rare cases, such as certain genetic disorders. Anaesthesia is well-documented a subset of mitochondrial diseases, but whether volatile toxic this setting has not been explored.MethodsWe exposed Ndufs4(−/−) mice, model Leigh syndrome, to isoflurane (0.2–0.6%), oxyge...
An explanation is given of the low value of Rλ ≡ Aλ/E(B − V ), the ratio of absolute to selective extinction deduced from Type Ia supernova observations. The idea involves scattering by dust clouds located in the circumstellar environment, or at the highest velocity shells of the supernova ejecta. The scattered light tends to reduce the effective Rλ in the optical, but has an opposite effect in...
This paper describes the clinical history of an adult male who was found to be suffering from subacute combined degeneration of the spinal cord. It is believed that this is the first report of this condition in Papua New Guinea.
We re-analyze the observed magnitude-redshift relation of type Ia supernovae (SNe Ia) and examine the possibility that the apparent acceleration of the cosmic expansion is not caused by dark energy but is instead a consequence of the large-scale inhomogeneities in the universe. We propose a method to phenomenologically describe the effects of the large-scale inhomogeneities without relying on t...
The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopathy resembling Leigh syndrome and die at ≈60 d of age. We previously reported that continuously bre...
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