Mitochondrial proton and electron leak have a major impact on mitochondrial coupling efficiency and production of reactive oxygen species. In the first part of this chapter, we address the molecular nature of the basal and inducible proton leak pathways, and their physiological importance. The basal leak is unregulated, and a major proportion can be attributed to mitochondrial anion carriers, w...

Two pore domain potassium (K2P) channels (KCNKx.x) cause K⁺ leak currents and are major contributors to resting membrane potential. Their roles in dorsal root ganglion (DRG) neurons normally, and in pathological pain models, are poorly understood. Therefore, we examined mRNA levels for 10 K2P channels in L4 and L5 rat DRGs normally, and 1 day and 4 days after unilateral cutaneous inflammation, ...

OBJECTIVE To determine the value of anastomotic leak testing of left-sided colorectal anastomoses. DESIGN Cohort analysis. SETTING Subspecialty practice at a tertiary care facility. PATIENTS Consecutive subjects were selected from a prospective colorectal database of 2627 patients treated between January l, 2001, and December 31, 2007. INTERVENTION Creation of left-sided colorectal anas...

382 ©2014 Society for Biomaterials

Leak detection techniques are not exclusively used for the vacuum products but are finding increasing applications in almost all industrial areas. Therefore, leak definition is evolving to accommodate the industry point of view. A leak always requires a flow of mass though the walls of a volume intended to be sealed. It usually results in escape or admission of liquids or gases from sealed comp...