In this issue of the Journal, Etzioni et al. (1) suggest a novel approach to estimating overdiagnosis in breast cancer. However, there is a key assumption in their method regarding the nature of overdiagnosis that is unlikely to hold and leads to an underestimate of the overdiagnosis rate. To understand this assumption, we need to go back to basic definitions. Lead time is the time from detecti...

• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version ...

• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version ...

catecholamine is a group of neurotransmitters that is believed to be responsible for the normal function of animal brain. physiological and behavioral changes of human body have been reported due to the damage of the brain function following lead exposure. due to the assumption of lead disposal in brain tissue with two year for its half-life, which results in alteration of brain function, we in...

Objective: To determine the impact of Lean Sigma (LS) on waiting time of patients at different stations of outpatient department (OPD), pre-surgical area and operation room (OR). Methods: In this prospective quality study Define, Measure, Analyse, Improve and Control (DMAIC) model of lean sigma was used for improvement. Lead time of patients during measure phase of DMAIC was assessed using time...