We investigated the effects of lead exposure during the pre- and postnatal period on the neurobehavioral development of female Wistar rats (70-75 days of age, 120-150 g) using a protocol of lead intoxication that does not affect weight gain. Wistar rats were submitted to lead acetate intoxication by giving their dams 1.0 mM lead acetate. Control dams received deionized water. Growth and neuromo...

BACKGROUND Zinc protoporphyrin (ZPP) has been used both as a screening and diagnostic test for overexposure to lead for nearly 30 years, although limitations for both purposes are recognized. METHODS We present longitudinal findings for ZPP and whole-blood lead in a man with two episodes of acute lead intoxication and review the literature on the use of ZPP. RESULTS AND CONCLUSIONS ZPP elev...

PURPOSE Gait impairment due to encephalopathy and neuropathy has been reported in carbon monoxide (CO) intoxication. Heterotopic ossification (HO) as a cause of gait impairment after CO intoxication has never been reported. In this study we report a patient with HO after CO intoxication. CASE REPORT A 21 year-old woman developed HO after CO intoxication, which resulted in progressive difficul...

A study of amoxicillin pharmacokinetics was conducted in healthy goats and goats with chronic lead intoxication. The intoxicated goats had increased serum concentrations of liver enzymes (alanine aminotransferase and γ-glutamyl transferase), blood urea nitrogen, and reactivated δ-aminolevulinic acid dehydratase compared to the controls. Following intravenous amoxicillin (10 mg/kg bw) in control...

In a study of signs and symptoms of lead intoxication in workers in lead processing industries in the Netherlands, use has been made of the apparatus described by Donath (1956) for semiquantitative determination of coproporphyrin excretion. The significance of this method in the screening of exposed groups of workers has been investigated. The method proved to be a valuable tool in the preventi...

Alcohol intoxication is a potentially under-recognised precipitant of Brugada syndrome. Higher pre-cordial electrocardiogram lead placement increases sensitivity of detecting the Brugada pattern.

Lead is a significant occupational and environmental hazard. Battery industry is one of the settings related to lead intoxication. Published information on the use of oral chelating agents for the treatment of anaemia in the context of acute lead intoxication is limited. The patient was a 33 year immigrant female worker in a battery manufacture for 3 months. She complained for malaise that has ...