Gilles C. Martin, MD, MSc; Gael Le Roux, PharmD; Damien Guindolet, PhD; Etienne Boulanger; Denis Hasle, MD; Emilie Morin; Dominique Vodovar, Catherine Vignal, Eric Gabison, Alexis Descatha, French PCC Research Group; Christine Tournoud; Jérôme Langrand; Hervé Laborde-Casterot; Nicolas Franchitto; Simon; Camille Paradis; Anne-Marie Patat; Patrick Nisse; Ramy Azzouz; Marie Deguigne; Marion Legeay

PELOUZE and Bernard (1850) first described the peripheral nature of curare paralysis. Further investigation, begun in 1852 by Claude Bernard, demonstrated the action of curarine to be at the neuromuscular junction (Bernard, 1856). Thus, one hundred years ago, the idea crystallized that the central actions of curare were unimportant or nonexistent, and was given form by such statements as " Mais...