The latissiimis dorsi muscle (LDM) receives its primary blood supply from a single nutrient artery located at its proximal insertion and it has not previously been established whether this effects the regional perfusion and nutrition of the muscle, A microelectrode technique was used to measure local oxygenation and permsion simultaneously at multiple sites in the rabbit LDM at rest, during and...

The drag-free satellites of LISA will maintain the test masses in geodesic motion over many years with residual accelerations at unprecedented small levels and time delay interferometry (TDI) will keep track of their differential positions at level of picometers. This may allow investigations of fine details of the gravitational field in the Solar System previously inaccessible. In this spirit,...

A central aim of modeling complex networks is to accurately embed in order detect structures and predict link node properties. The Latent Space Model (LSM) has become a prominent framework for embedding includes the Distance (LDM) Eigenmodel (LEM) as most widely used LSM specifications. For latent community detection, space LDMs been endowed with clustering model whereas LEMs have constrained p...

OBJECTIVE Secondary reconstruction after breast-conserving surgery is generally challenging because of the nature of irradiated tissue. The aim of this study was to validate the use of latissimus dorsi myocutaneous (LDM) flaps for secondary breast reconstruction after breast-conserving surgery. METHODS Fifteen consecutive patients who underwent secondary reconstruction with an LDM flap after ...

The recent clinical successes of antiangiogenic drug-based therapies have also served to highlight the problem of acquired resistance because, similar to other types of cancer therapy, tumors that initially respond eventually stop doing so. Consequently, strategies designed to delay resistance or treat resistant subpopulations when they arise have assumed considerable importance. This requires ...

OBJECTIVE Lenalidomide (LDM) is an immunomodulatory and anti-angiogenic drug which has been shown to be effective in several haematological disorders (multiple myeloma [MM], myeloid metaplasia with myelofibrosis [MF] and myelodysplastic syndrome [MDS]). The objective of this study is to evaluate the effectiveness and tolerability of LDM in our patients. METHOD Retrospective observational stud...

Sixty-eight patients with moderate (n = 15) or severe (n = 53) aplastic anemia were entered into a prospective, randomized, two-arm treatment study comparing antihuman thymocyte globulin (ATG), lower-dose methylprednisolone (LDM) and oxymetholone to ATG, higher-dose methylprednisolone (HDM), and oxymetholone. There were no differences between the two groups when comparing age, sex, etiology of ...

G protein-coupled receptors (GPCRs) play crucial roles in cell physiology and pathophysiology. There is increasing interest in using structural information for virtual screening (VS) of libraries and for structure-based drug design to identify novel agonist or antagonist leads. However, the sparse availability of experimentally determined GPCR/ligand complex structures with diverse ligands impe...

Objective: Dynamic aortomyoplasty using Latissimus Dorsi muscle (LDM) has been shown to improve myocardial function. However, systematic examination of the effects of stimulation parameters on aortic wrap function has not been done. Thus, the present study measures the direct effect of stimulation voltage, pulse train duration, frequency of the pulses, and the duration of the stimulation delay ...

scientific evidence regarding the efficacy and safety of the ldm approach in the treatment of psoriasis vulgaris, and positive preliminary data regarding the oral administration of low dose activated cytokines for vitiligo and atopic dermatitis treatment, support the ldm-based therapeutic approach for many dermatological diseases. ldm suggests the use of low-doses of activated biological molecu...