The primary activation of the epidermal growth factor receptor (EGFR) has become a prominent target for molecular therapies against several forms of cancer. But despite considerable progress during the last years, many of its aspects remain poorly understood. Experiments on lateral spreading of receptor activity into ligand-free regions challenge the current standard models of EGFR activation. ...

Observations collected from a fast-flowing buoyant river plume entering the head of Doubtful Sound, New Zealand, were analysed to examine drivers lateral spreading. The near-field is characterised by flow speeds over 2 ms −1 , and strong stratification ( N > 0.1 s −2 ), resulting in enhanced shear which supports elevated turbulence dissipation rates (ϵ 10 −3 W kg ). Estimates spreading d...

Previously, we have shown that spatial attention to a visual stimulus can spread across both space and modality to a synchronously presented but task-irrelevant sound arising from a different location, reflected by a late-onsetting, sustained, negative-polarity event-related potential (ERP) wave over frontal-central scalp sites, probably originating in part from the auditory cortices. Here we e...

Endoscopic submucosal dissection (ESD) in the colon bears a significant risk of complications due to the fragility of the wall, reduced maneuverability of the endoscope and lack of countertraction. Lately, tunneling methods such as the pocket creation method and the single/multiple tunneling technique have been introduced in an effort to overcome these difficulties [1-3]. Here we describe a sin...

Voltage-controlled lateral potential superlattices are used to dramatically increase the lifetime of photogenerated carriers in a quantum well. These long lifetimes, together with the ability to deliberately trigger radiative recombination, enable us to directly visualize the spreading character of nonlinear Maxwell relaxation of 2D charges along narrow channels. Our system allows for temporal ...

The rare case of 75-years-old female patient was presented in this paper. She reported hoarseness in addition to pharyngeal pain, dysphagia and medium level dyspnea. Her exploration revealed a wide hematoma of the left lateral wall of orohypopharynx spreading to the left aryepiglottic fold, left aryepiglottic cartilage, false and true vocal fold and later to left lateral and posterior tracheal ...

Spreading resistance analysis on ultrashallow structures is complicated by the interaction of bevel rounding with geometric effects associated with lateral boundaries. When a spreading resistance probe is stepped from the original sample surface, across the rounded region at the bevel edge and onto the bevel, the resistance increases. Some of the increase is the result of approaching the latera...

The recent availability of large amounts high-quality data from post-disaster field reconnaissance enables an exploration the use machine learning (ML) approaches to predict earthquake-induced damage. 2011 Christchurch earthquake in New Zealand caused widespread liquefaction and lateral spreading, development ML models spreading was enabled by high-resolution for displacements, ground shaking, ...