People living with Amyotrophic Lateral Sclerosis (pwALS) face many challenges to taking adequate nutrition and hydration (1). Reduced dietary intake, combined raised resting energy expenditure (REE) (2), contribute the high prevalence of malnutrition in ALS (3), low BMI weight loss being independent prognostic indicators survival (4). There is a lack evidence focusing on nutritional management ...

The role of the central nervous system in regulating food intake was probably suggested first by the discovery that either obesity or emaciation may occur in patients with nervous diseases. For a while these observations were not properly evaluated, because emphasis was laid upon the obesity as such, or the leanness, rather than upon the changed eating habits responsible for the clinical pictur...

OBJECT One quarter of patients with anorexia nervosa have a poor outcome and continue to suffer chronically or die. Electrical brain stimulation may be of therapeutic benefit in some of these patients; however, the brain target for inducing symptom relief is unknown. In this study, the authors evaluated the effects of acute and chronic electrical stimulation in the lateral hypothalamus on food ...

Melanin-concentrating hormone (MCH) and orexin-A are orexigenic peptidergic neurotransmitters produced primarily in the lateral hypothalamus. Because two other hypothalamic peptides, neuropeptide Y and agouti-related peptide, increase food intake by a mechanism that depends on activation of opioid receptors, we assessed whether MCH or orexin-A also elicits food intake via opioid receptor activa...

BACKGROUND There is considerable evidence that abnormal zinc homeostasis is related to amyotrophic lateral sclerosis (ALS) pathogenesis, and malnutrition is an independent prognostic factor for worsened survival of ALS patients. OBJECTIVE To evaluate the dietary intake and zinc status in patients with ALS, treated in a specialized outpatient facility in Natal, Brazil. METHODS Twenty patient...

introduction: the septal region is part of the telencephalon and is a component of the limbic system. the lateral septal area (ls); largest nuclear mass in this region, plays a pivotal role in various physiological processes, such as aggression, emotion, thermoregulation, water and food intake and sexual behaviour. to support the functional analysis of this brain area in the rat, the sources of...

WOLF, GEORGE, AND DAVID QUARTERMAIN. Sodium &ride intake of adrenalectomi~ed rats with lateral hypothalamic lesions. Am. J. Physiol. ZIZ(I): 113-118. Ig67.---Rats which had recovered from a temporary adipsia and aphagia following lateral hypothalamic lesions were adrenalectomized and given access to a saline solution to determine whether they would respond to the heightened need for sodium by i...

The role of gamma amino butyric acid A receptors/neurons of the hypothalamic, endocrine and alimentary systems in the food intake seen in hunger was studied in 20 h food-deprived rats. Food deprivation decreased blood glucose, serum insulin and produced hyperphagia. The hyperphagia was inhibited by subcutaneous or ventromedial hypothalamic administration of gamma amino butyric acid A antagonist...

Rats with either bilateral electrolytic or sham lesions of the ventrolateral portion of the lateral parabrachial nucleus (VLLPBN) were implanted with latex balloons that lay at the right superior vena cava/atrial junction (RSVC/AJ). Water intake in response to isoproterenol was measured both with and without inflation of the balloon. Water intake of the sham-lesioned rats was significantly depr...