Newcastle disease virus (NDV) causes a devastating poultry disease worldwide. Frequent outbreaks of NDV in chickens vaccinated with conventional live vaccines suggest a need to develop new vaccines that are genetically matched against circulating NDV strains, such as the genotype V virulent strains currently circulating in Mexico and Central America. In this study, a reverse genetics system was...

The principal molecular determinant of virulence of Newcastle disease virus (NDV) is the amino acid sequence at the fusion cleavage activation site. To extend the understanding of the role of the fusion cleavage activation site in NDV virulence, the pathogenesis in chickens of a lentogenic LaSota isolate and two infectious clones, NDFL and NDFLtag, were compared. NDFL is an infectious clone of ...

BACKGROUND Chemotherapy is one of the antitumor therapies used worldwide in spite of its serious side effects and unsatisfactory results. Many attempts have been made to increase its activity and reduce its toxicity. 5-Fluorouracil (5-FU) is still a widely-used chemotherapeutic agent, especially in combination with other chemotherapies. Combination therapy seems to be the best option for target...

The paper [FGTQ14] established fibrewise stability of random absolutely continuous invariant measures (acims) for cocycles of random Lasota-Yorke maps under a variety of perturbations, including “Ulam’s method”, a popular numerical method for approximating acims. The expansivity requirements of [FGTQ14] were that the cocycle (or powers of the cocycle) should be “expanding on average” before app...

Newcastle disease virus (NDV) and Salmonella Pullorum have significant damaging effects on the poultry industry, but no previous vaccine can protect poultry effectively. In this study, a recombinant-attenuated S. Pullorum strain secreting the NDV hemagglutinin-neuraminidase (HN) protein, C79-13ΔcrpΔasd (pYA-HN), was constructed by using the suicide plasmid pREasd-mediated bacteria homologous re...

Recently published observations of VY Scl stars in their low, long-intermediate and high states confirm our model (Hameury & Lasota 2002) according to which accretion disks in such systems must vanish when their temperature corresponds to thermally unstable configurations. An observational confirmation of the hypothesis that the disk disappearance is caused by magnetic effects would have import...

We study the existence, uniqueness and rate of decay of correlation of equilibrium measures associated to robust classes of non-uniformly expanding local diffeomorphisms and Hölder continuous potentials. The approach used in this paper is the spectral analysis of the Ruelle-PerronFrobenius transfer operator. More precisely, we combine the expanding features of the eigenmeasures of the transfer ...

Abstract Background The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is a major antigen that can induce protective antibodies in poultry. However, its antigenic epitopes have not been fully elucidated. Therefore, defining the linear HN, especially neutralizing epitopes, will be useful for revealing characterization. Methods In this study, we analyzed B-cell immunodo...