نتایج جستجو برای: lasb

تعداد نتایج: 140  

Journal: :Journal of bacteriology 2001
P Branny J P Pearson E C Pesci T Köhler B H Iglewski C Van Delden

The Pseudomonas aeruginosa las (lasR-lasI) and rhl (rhlR-rhlI) quorum-sensing systems regulate the expression of several virulence factors, including elastase and rhamnolipid. P. aeruginosa strain PR1-E4 is a lasR deletion mutant that contains a second, undefined mutation which allows production of elastase and rhamnolipid despite a nonfunctional las system. We have previously shown that this s...

رهبر زارع, محیا , نوربخش, فاطمه , هنرمند جهرمی, سحر ,

سابقه و هدف : سودوموناس آئروژینوزا یکی از پاتوژن های مهم در ایجاد عفونت­های اکتسابی از بیمارستان در سراسر جهان می­باشد. این باکتری دارای ژنهای ویرولانس متعددی است که در بیماریزایی و عفونت نقش مهمی دارند. هدف از انجام تحقیق، شناسایی ژنهای ویرولانس lasB, plcH, plcN‏ در سودوموناس آئروژینوزا جدا شده از نمونه­های انسانی و تعیین الگوی مقاومت آنتی­بیوتیکی بوده است.  مواد و روش ها: این مطالعه بر روی 1...

Journal: :Brazilian Journal of Biology 2022

Abstract The effects of Calcium (Ca+2) on virulence and some parameters should be analyzed in this study. Pseudomonas aeruginosa Gram (-) Bacillus cereus (+) were used. Both bacteria are soil bacteria. In study; the effect Ca+2 protease, amylase, LasB elastolytic assay, H2O2, pyorubin biofilm metabolites these investigated during 24 hour time. study, production secondary P. B. was presented for...

Journal: :Applied and environmental microbiology 2007
Takenori Ishida Tsukasa Ikeda Noboru Takiguchi Akio Kuroda Hisao Ohtake Junichi Kato

N-octanoyl cyclopentylamide (C8-CPA) was found to moderately inhibit quorum sensing in Pseudomonas aeruginosa PAO1. To obtain more powerful inhibitors, a series of structural analogs of C8-CPA were synthesized and examined for their ability to inhibit quorum sensing in P. aeruginosa PAO1. The lasB-lacZ and rhlA-lacZ reporter assays revealed that the chain length and the ring structure were crit...

2016
Beatrix Tettmann Christine Niewerth Frank Kirschhöfer Anke Neidig Andreas Dötsch Gerald Brenner-Weiss Susanne Fetzner Joerg Overhage

The 2-alkyl-3-hydroxy-4(1H)-quinolone 2,4-dioxygenase HodC was previously described to cleave the Pseudomonas quinolone signal, PQS, which is exclusively used in the complex quorum sensing (QS) system of Pseudomonas aeruginosa, an opportunistic pathogen employing QS to regulate virulence and biofilm development. Degradation of PQS by exogenous addition of HodC to planktonic cells of P. aerugino...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
M W Calfee J P Coleman E C Pesci

Pseudomonas aeruginosa is an opportunistic pathogen that controls numerous virulence factors through intercellular signals. This bacterium has two quorum-sensing systems (las and rhl), which act through the intercellular signals N-(3-oxododecanoyl)-l-homoserine lactone (3-oxo-C(12)-HSL) and N-butyryl-l-homoserine lactone (C(4)-HSL), respectively. P. aeruginosa also produces a third intercellula...

2015
Fohad Mabood Husain Iqbal Ahmad Mohd Shahnawaz Khan Nasser Abdulatif Al-Shabib

Trigonella foenum-graecum L. (Fenugreek) is an important plant of the Leguminosae family known to have medicinal properties. However, fraction based antiquorum sensing and antibiofilm activities have not been reported from this plant. In the present study T. foenum-graecum seed extract was sequentially fractionated and sub-MICs were tested for above activities. The methanol fraction of the extr...

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