Neuropilin 2 is a receptor for class III semaphorins and for certain members of the vascular endothelial growth factor family. Targeted inactivation of the neuropilin 2 gene (Nrp2) has previously shown its role in neural development. We report that neuropilin 2 expression in the vascular system is restricted to veins and lymphatic vessels. Homozygous Nrp2 mutants show absence or severe reductio...

background: isolated right bundle branch block (rbbb) is a common finding in the general population. the atrioventricular node (avn) artery contributes to the blood supply of the right bundle branch. our hypothesis was that the anatomy of the avn artery and the pattern of dominancy differ between subjects with and without rbbb. methods: w e retrospectively studied the coronary angiography of 92...

iatrogenic coronary artery dissection during coronary angiography with or without rupture is a rare but feared complication . we herein report a case of iatrogenic left main coronary artery dissection in a 49-year-old female. admitted to our hospital with a recent history of severe hypotension, she develpled apnea during angiography. she was intubated  and resuscitated with an epinephrine infus...

a 48-year-old woman was admitted to the emergency department with complaints of typical chest pain, cold sweat, and dyspnea of 24 hours’ duration. she had a history of hypertension, hyperlipidemia, and diabetes mellitus for many years. on admission, her electrocardiogram (ecg) revealed normal sinus rhythm and dynamic t inversion in the precordial leads. her enzyme levels were normal. transthora...

Augmented reactivity of the skin vessels of the hind limbs of dogs to doses of 1-epinephrine in the physiologic range could not be detected following conventional sympathectomy. Larger doses of epinephrine resulted in exaggerated reactions. Augmented reactivity of these vessels to physiologic doses of epinephrine was detectable if total chclinergic as well as adrenergic denervation of the limb ...

Results: The junctional zone showed basement membrane thickening and the vessels showed endothelial interruptions. Some endothelial cells were degenerated and a few were apoptotic. Endothelial cells showed increased microfilaments with foci of detachment from the underlying basement membrane. Larger blood vessels showed large plump endothelial cells alternating with attenuated ones. There was a...

Coronary vessels are squeezed by the surrounding myocardium during systole, impeding blood flow specifically in the subendocardium. To study the myocardial compression effect, we applied pulsatile transvascular pressure to isolated, cannulated subendocardial (Endo) and subepicardial (Epi) resistance arteries. Pressure pulsation at 0.5 to 2.5 Hz between 20 and 100 mmHg induced dilation of precon...

The process of revascularization of free grafts of the extensor digitorum longus muscle in rats has been studied by gross, histological and electron microscopic methods. During the first day after transplantation the muscle is entirely avascular, and it consists of a thin peripheral zone of surviving muscle fibers and a large central area of ischemic muscle. The original blood vessels of the gr...

Mechanism of coronary spasm was examined regarding endothelium-related relaxation and contraction produced by smooth muscle cells of spastic vessels isolated from Göttingen miniature pigs. In these pigs, coronary artery spasm was documented angiographically in vivo three months after endothelial denudation, and spastic and control segments of the coronary artery were suspended in organ chambers...

Using a frequency-domain Womersley-type model, we previously simulated pulsatile blood flow throughout the coronary arterial tree. Although this model represents a good approximation for the smaller vessels, it does not take into account the nonlinear convective energy losses in larger vessels. Here, using Womersley's theory, we present a hybrid model that considers the nonlinear effects for th...