King, A. 2001. Evaluation of Alginate Microcapsules for Use in Transplantation of Islets of Langerhans. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1072. 43 pp. Uppsala. ISBN 91554-5113-6 Transplantation of islets of Langerhans is a potential treatment of type 1 diabetes that aims to restore normal glucose homeostasis. Microencap...

Islets of Langerhans are microorgans scattered throughout the pancreas, and are responsible for synthesizing and secreting pancreatic hormones. While progress has recently been made concerning cell differentiation of the islets of Langerhans, the mechanism controlling islet morphogenesis is not known. It is thought that these islets are formed by mature cell association, first differentiating i...

TABLE 1 Landmarks in the history of the islets of Langerhans 1869 First description of pancreatic islets by Langerhans 1902 First tumour of the islets described by Nicholls 1922 Discovery of insulin by Banting and Best 1923 Discovery of glucagon by Murlin and colleagues 1924 Harris postulates the possibility of insulinoma 1927 Wilder extracts insulin from a malignant pancreatic tumour explored ...

OBJECTIVES Ghrelin is a peptide hormone that has been shown to have numerous central and peripheral effects. The central effects including GH secretion, food intake, and energy homeostasis are partly mediated by Kiss1- KissR signaling pathway. Ghrelin and its receptor are also expressed in the pancreatic islets. Ghrelin is one of the key metabolic factors controlling insulin secretion from the ...

Evidence exists for the presence of a discrete tissue renin-angiotensin system (RAS) in mouse and rat pancreas that is thought largely to be associated with the vasculature. To investigate this in the human pancreas, and to establish whether the cellular sites of RAS components include the islets of Langerhans, we used immunocytochemistry to localise the expression of angiotensin II (AT1) recep...

Islets of Langerhans are microorgans scattered throughout the pancreas, and are responsible for synthesizing and secreting pancreatic hormones. While progress has recently been made concerning cell differentiation of the islets of Langerhans, the mechanism controlling islet morphogenesis is not known. It is thought that these islets are formed by mature cell association, first differentiating i...

Transthyretin (TTR) is a major amyloid fibril protein in certain systemic forms of amyloidosis. It is a plasma protein, mainly synthesized by the liver but expression occurs also at certain minor locations, including the endocrine cells in the islets of Langerhans. With the use of immunohistochemistry and in situ hybridization, we have studied the distribution of transthyretin-containing cells ...

TABLE 1 Landmarks in the history of the islets of Langerhans 1869 First description of pancreatic islets by Langerhans 1902 First tumour of the islets described by Nicholls 1922 Discovery of insulin by Banting and Best 1923 Discovery of glucagon by Murlin and colleagues 1924 Harris postulates the possibility of insulinoma 1927 Wilder extracts insulin from a malignant pancreatic tumour explored ...