RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. To meet the challenge of gene therapy and deliver small-interfering RNA (siRNA) into the cytoplasm of target cells, several barriers must be overcome. The most widely used polymeric vector is polyethylenimine (PEI) but its cytotoxicity limits its use in vivo. As a safe alternative, we designed ...

Central MessageThe persistent progress in the field of mechanical circulatory support children has led to increased use, expanded device utilization, and improved survival. The Application (MCS) become mainstream. However, it continues be associated with significant morbidity. MCS In current review, we focus on publications from year 2020 that examined role children. We include related total ar...

Organelles of the plant cell cooperate to synthesize and secrete a strong yet flexible polysaccharide-based extracellular matrix: wall. Cell wall composition varies among species, across types within plant, different regions single wall, in response intrinsic or extrinsic signals. This diversity makeup is underpinned by common cellular mechanisms for production. Cellulose synthase complexes fun...

When conceptualizing “The Unexpected Caribbean” special issue for the journal of Women, Gender, and Families Color, we, as editors, sought to contest many stereotypical visualizations Caribbean its diasporas highlight some unexpected counternarratives innovations in representation that appear literature, arts, society. Focusing on women, gender, families allowed us consider how women—typically ...

Hedgehog (Hh) proteins belong to a class of morphogens involved in many biological processes during embry-onic development; they are relatively silent during normal adult life although they may be recruited postnatally in re-sponse to tissue injury. Three secreted proteins have been identified: Sonic hedgehog (Shh), Desert hedgehog and Indianhedgehog. The interaction of Hh ligand wi...