Bronchodilators are the cornerstone of symptomatic chronic obstructive pulmonary disease (COPD) treatment. They are routinely recommended for symptom reduction, with a preference of long-acting over short-acting drugs. Bronchodilators are classified into two classes based on distinct modes of action, i.e., long-acting antimuscarinics (LAMA, once-daily and twice-daily), and long-acting β2-agonis...

OBJECTIVE We investigated the effect of treatment with inhaled drugs on changes in mood, focusing on depression and anxiety during treatment in patients with newly diagnosed chronic obstructive pulmonary disease (COPD). METHODS We prospectively selected new COPD patients from three Seoul National Hospitals. Participants underwent face-to-face interviews to evaluate clinical characteristics an...

LAMA-2011 (Richter and Westphal 2010) is the clear winner of the sequential satisficing track in the latest International Planning Competition (IPC-2011). It finds a first solution by Greedy Best-First Search (GBFS), and then continues to improve solutions using restarting weighted A* (Richter, Thayer, and Ruml 2010). Diverse Anytime Search (DAS) (Xie, Valenzano, and Müller 2013) is a metaalgor...

We provide a MAC called LAMA with 128 bits output, there have not found a attack which is better than the exhaustive search attack for the MAC, which has a implementation in about 5 / cycles byte .

The feasibility of determining left atrial volumes (LAV) from LA echo dimensions was assessed in 36 children (group I) with normal cineangiographically determined LAV and 16 children (group II) with LAV overload. Conventional LA echo dimensions, obtained within 24 hours of cardiac catheterization, were compared to the angiographic LA anterior-posterior minor axes (LAmA) and LAV. There was excel...

Admissible heuristics are essential for optimal planning in the context of search algorithms like A*, and they can also be used in the context of suboptimal planning in order to find quality-bounded solutions. In satisfacing planning, on the other hand, admissible heuristics are not exploited by the best-first search algorithms of existing planners even when a time window is available for impro...

Bronchodilators are the cornerstone of the treatment of chronic obstructive pulmonary disease (COPD). In particular, the most commonly used drugs are inhaled long-acting agents, including long-acting β 2 -adrenergic agonists (LABAs) and long-acting muscarinic receptor antagonists (LAMAs). The combination of a LABA with a LAMA, i.e. of mole cules characterized by different mechanisms of action, ...

The genetic organization, expression, and regulation of the celB locus of the hyperthermophilic archaeon Pyrococcus furiosus were analyzed. This locus includes the celB gene, which codes for an intracellular beta-glucosidase, and a divergently orientated gene cluster, adhA-adhB-lamA, which codes for two alcohol dehydrogenases and an extracellular beta-1,3-endoglucanase that is transcribed as a ...

The in-memory cache system is a performance-critical layer in today’s web server architecture. Memcached is one of the most effective, representative, and prevalent among such systems. An important problem is memory allocation. The default design does not make the best use of the memory. It fails to adapt when the demand changes, a problem known as slab calcification. This paper introduces loca...

Purpose Inappropriate use of an inhaled corticosteroid (ICS) for COPD has clinical and economic disadvantages. This retrospective analysis of The UK Health Improvement Network (THIN) database identified factors influencing treatment escalation (step-up) from a long-acting muscarinic antagonist (LAMA) to triple therapy (LAMA + long-acting β-agonist-ICS). Secondary objectives included time to ste...