PURPOSE To determine whether activity of carbohydrate metabolism enzymes (aldolase, pyruvate kinase, isocitrate dehydrogenase, and malate dehydrogenase) are altered in the glaucomatous trabecular meshwork (TM) compared to controls. METHODS Tissue specimens were obtained from trabeculectomy (n=45 open angle glaucoma; Caucasian, average age 61+/-8 years of age of both genders) and from cadaver ...

UNLABELLED (See the editorial commentary by Morris and Masur, on pages 203-204.) BACKGROUND Improved noninvasive diagnostic tests for Pneumocystis jirovecii pneumonia (PCP) are needed. We evaluated the test characteristics of plasma (1 → 3)-β-D-glucan (β-glucan) for HIV-related PCP among a large group of patients presenting with diverse opportunistic infections (OIs). METHODS The study popu...

Pyruvate dehydrogenase kinases (PDKs) are key enzymes in glucose metabolism, negatively regulating pyruvate dehyrogenase complex (PDC) activity through phosphorylation. Inhibiting PDKs could upregulate PDC activity and drive cells into more aerobic metabolism. Therefore, PDKs are potential targets for metabolism related diseases, such as cancers and diabetes. In this study, a series of computer...

arginine vasopressin as a supplementary vasopressor in septic shock restores vascular tone and mean arterial pressure, meanwhile decreases dose and exposure time to catecholamines. the objective of this study was to evaluate the effect of vasopressin on lactate and lactate clearance as markers of tissue perfusion during septic shock. in this prospective, randomized, controlled trial, 30 patient...

This study evaluated the levels of D(–)-lactate and L(+)-lactate, ratio to total lactate (D(–)-lactate + L(+)-lactate) 15 lactic acid bacteria (LAB) using an enzymatic method. L(+)-lactate in LAB ranged from 0.31 13.9 mM 0.76 39.3 mM, respectively, Bifidobacterium sp.; 1.08 11.7 0.69–13.0 Lactobacillus 0.72 20.3 0.98 32.3 Leuconostoc sp., 33.0 39.2 Pediococcus acidilacti KCCM 11747. The range D...

Background: Keratosis rubra pilaris is a common condition with an estimated percentage of 40% involvement in the population. This condition is inherited as an autosomal dominant trait and more commonly involves patients with dry skin. In the current study, we evaluated the efficacy of intense pulsed light (IPL) plus ammonium lactate versus ammonium lactate alone in the treatmen...

a Department of Informatics Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal b Department of Informatics Engineering, Faculty of Sciences and Technology, Rua Sílvio Lima, Universidade de Coimbra— Pólo II, 3030-790 Coimbra, Portugal c Centre for Informatics and Systems, Universidade de Coimbra, DEI, Pólo II, Pinhal de Marrocos, 3030-290 Co...