1 Biomechanics Section, KU Leuven, Celestijnenlaan 300C, 3001 Leuven, Belgium 2 Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium 3 Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium 4 Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU L...

A new non-linear method for design and analysis of solid state power amplifiers is presented and applied to an aluminum gallium nitride, gallium nitride (AlGaN-GaN) high electron-mobility transistor (HEMTs) on silicon-carbide (SiC) substrate for Ku band (12.4 13.6 GHz) applications. With combining output power of 8 transistors, maximum output power of 46.3 dBm (42.6 W), PAE of 43% and linear ga...

Karar verme ve risk alma davran??lar? bireylerin özel çal??ma hayatlar?nda önemli etkiye sahiptir. Bireylerin karar aras?nda farkl?l?klar görülebilmektedir. Öte yandan birey, do?umundan itibaren, kendisiyle benzer y?llarda do?an di?er ki?ilerin olu?turdu?u ku?ak ad? verilen grubun bir parças? olur. Ku?aklar çe?itli özellikler aç?s?ndan görülmektedir. davran??? da ku?aklar olabilece?i yaz?nda ye...

The Ku70/80 autoantigens (Ku) are the DNA-binding components of a DNA-dependent protein kinase (PK) involved in DNA double strand breaks repairing a V(D)J recombination. Because apoptosis is associated with DNA fragmentation and, consequently, creation of double strand breaks, and a variety of DNA-damaging drugs kill tumor cells by apoptosis, we tested the impact of Ku deficiency on the sensiti...

Ku is a heterodimeric protein with high binding affinity for ends, nicks, and gaps in double-stranded DNA. Both in mammalian cells and in budding yeast, Ku plays a role in nonhomologous end joining in the double strand break repair pathway. However, Ku has a more significant role in DNA repair in mammalian cells compared with yeast, in which a homology-dependent pathway is the predominant one. ...

We have investigated whether the Ku complex is involved in regulating DNA replication in the yeast Saccharomyces cerevisiae. We find that Ku proteins control the replication time of telomeric regions; replication origins located close to telomeres or within subtelomeric repeat sequences normally initiate late, but are activated much earlier in mutants lacking Ku function. In contrast, origins d...