A further study has been made of the relationship of reactions of the Krebs cycle to the propagation of influenza virus. By the administration of sublethal doses of sodium fluoroacetate which were found to increase the concentration of citrate in the mouse lung, it was possible to demonstrate a blocking of the citric acid cycle in that organ. Further, the intraperitoneal administration of these...

It is possible that the virus formed in infected tissue derives from an abnormal sequence of some normal metabolic processes of the cell. Thus those enzymatic reactions which lead to the formation of cellular components may also be involved in viral synthesis. One approach to this problem of viral biogenesis is to determine which enzyme systems of the host cell are essential to the process. It ...

Studies on the metabolism of the strict aerobe Micrococcus sodonensis revealed that a considerable accumulation of a-ketoglutarate and glutamate occurred. This accumulation was in evidence, both during growth on complex media and during growth on chemically defined media with acetate as the sole carbon source. The major pathway of terminal respiration in aerobically growing microorganisms appea...

Studies on the metabolism of the strict aerobe Micrococcus sodonensis revealed that a considerable accumulation of a-ketoglutarate and glutamate occurred. This accumulation was in evidence, both during growth on complex media and during growth on chemically defined media with acetate as the sole carbon source. The major pathway of terminal respiration in aerobically growing microorganisms appea...

In recent years evidence that suggests the operation of the Krebs cycle in plant tissues has accumulated. Studies by Millerd et al (10), Laties (8), Brummond and Burris (4), Biale and Young (3), and Smillie (14), have demonstrated that mitochondria, isolated by differential centrifugation of tissue homogenates, can carry out oxidation with concomitant phosphorylation of Krebs cycle acids. Davie...