Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...

Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...

The aim of this contribution is a survey of different nucleation and growth kinetics terms effects on modeling results of KNO3 Continuous Mixed Suspension Mixed Product Removal (CMSMPR) crystallizer. By studying the four different states in modeling, results show that, although these terms for similar crystallization system and operating conditions are similar, there is very different dynamic b...

MODELING OF HYDRATION KINETICS AND SHRINKAGE OF PORTLAND CEMENT PASTE

nowadays, hydrogels are widely used as wound dressings in biomedical applications. similar to other types of the moist (wet) wound dressings, it is necessary to have sufficient information about their dehydration kinetics during the pre-usage period (e.g. storage duration) and also the wound healing process. in this work, hydrogel wound dressings based on polyvinyl alcohol were prepared by cycl...

A novel soy-based epoxy resin system was synthesized by the process of transesterification and epoxidation of regular soy bean oil, which has the potential to be widely usable in various composite manufacturing processes. Cure kinetics and rheology are two chemical properties commonly required in process modeling. In this work, the cure kinetics and rheology of the soy-based resin system were m...

     Nowadays, hydrogels are widely used as wound dressings in biomedical applications. Similar to other types of the moist (wet) wound dressings, it is necessary to have sufficient information about their dehydration kinetics during the pre-usage period (e.g. storage duration) and also the wound healing process. In this work, hydrogel wound dressings based on polyvinyl alcohol were prepared by...

for large and complex reacting systems, computational efficiency becomes a critical issue in process simulation, optimization and model-based control. mechanism simplification is often a necessity to improve computational speed. we present a novel approach to simplification of reaction networks that formulates the model reduction problem as an optimization problem and solves it using genetic al...